PMID- 16772125
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 168
IP  - 1
DP  - 2006 Jul 1
TI  - Pediatric T-cell acute lymphoblastic leukemia with aberrations of both MLL loci.
PG  - 77-9
AB  - Translocations involving the MLL gene at 11q23 have been implicated in acute 
      lymphoblastic leukemia (ALL), as well as acute myeloid leukemia (AML). Such 
      translocations result in gain of function fusion proteins that drive cell 
      proliferation. Except in cases of T-cell ALL, MLL rearrangement is typically 
      associated with a poor prognosis. We report a case of T-cell ALL with a 
      t(11;19)(q23;p13.3) and deletion of the other chromosome 11 homolog at band q23. 
      Fluorescence in situ hybridization (FISH) analyses confirmed involvement of the 
      MLL loci in both the translocation and deletion. This case is unique in that 
      deletions of 11q23 reported in ALL generally do not involve MLL. We are unaware 
      of a previous report showing rearrangement of the MLL loci on both chromosome 11 
      homologues.
FAU - Quigley, Denise I
AU  - Quigley DI
AD  - Department of Pathology and Laboratory Medicine, Medical University of South 
      Carolina, Charleston, SC 29425, USA. quigleyd@musc.edu
FAU - Wolff, Daynna J
AU  - Wolff DJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (KMT2A protein, human)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Child
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Female
MH  - *Gene Deletion
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Myeloid-Lymphoid Leukemia Protein/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2006/06/15 09:00
MHDA- 2006/07/28 09:00
CRDT- 2006/06/15 09:00
PHST- 2005/11/28 00:00 [received]
PHST- 2006/01/30 00:00 [revised]
PHST- 2006/02/08 00:00 [accepted]
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - S0165-4608(06)00101-4 [pii]
AID - 10.1016/j.cancergencyto.2006.02.004 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2006 Jul 1;168(1):77-9. doi: 
      10.1016/j.cancergencyto.2006.02.004.