PMID- 16772706
OWN - NLM
STAT- MEDLINE
DCOM- 20060720
LR  - 20190911
IS  - 0388-1350 (Print)
IS  - 0388-1350 (Linking)
VI  - 31
IP  - 2
DP  - 2006 May
TI  - Effects of stage and degree of restricted feeding on pregnancy outcome in 
      rabbits.
PG  - 169-75
AB  - This study's aim is to investigate the relationship between stage and degree of 
      restricted feeding during the gestation period and occurrence of abortion, 
      premature birth or fetal damage in rabbits. The study was composed of 5 groups of 
      pregnant Kbl:NZW rabbits that consisted of 8 animals each. These groups were 
      subjected to restricted feeding in the following ways: (A) control group, free 
      access to food, (B) 60 g per day from gestational days (GD) 6 to 18 (middle 
      period), (C) 20 g per day from GD 6 to 18, (D) 20 g per day from GD 19 to 28 
      (post-middle period), and (E) 20 g per day from GD 6 to 28 (middle and 
      post-middle periods). Even though all dams in Groups A, B and C went to full 
      term, abortion or premature birth occurred to 2/8 and 8/8 dams in Groups D and E, 
      respectively. Fetal lethality increased in Group C, which was subjected to 
      restricted feeding at 20 g/head/day in the middle period. Slight inhibition of 
      fetal growth was recorded only in Group D, which was subjected to restricted 
      feeding in the post-middle period. Restricted feeding at 20 g/head/day in the 
      middle period induced no abortion or premature birth, but increased fetal 
      lethality that in the middle and post-middle periods resulted in abortion or 
      premature birth of all dams, and that in the post-middle period resulted in 
      abortion or premature birth at low incidence and slightly inhibited fetal growth. 
      These results demonstrated that the post-middle period is vulnerable to effects 
      of reduced food consumption in pregnant rabbits.
FAU - Matsuoka, Tetsuya
AU  - Matsuoka T
AD  - Kannami Laboratory, Bozo Research Center Inc., Japan.
FAU - Mizoguchi, Yasumoto
AU  - Mizoguchi Y
FAU - Serizawa, Kotaro
AU  - Serizawa K
FAU - Ishikura, Toshikazu
AU  - Ishikura T
FAU - Mizuguchi, Hiroyasu
AU  - Mizuguchi H
FAU - Asano, Yuzo
AU  - Asano Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
SB  - IM
MH  - Animals
MH  - Congenital Abnormalities/*embryology
MH  - Embryonic Development/physiology
MH  - Female
MH  - Fetal Development/physiology
MH  - Food Deprivation/*physiology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy, Animal/*physiology
MH  - Rabbits
MH  - Reproduction/*physiology
EDAT- 2006/06/15 09:00
MHDA- 2006/07/21 09:00
CRDT- 2006/06/15 09:00
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2006/07/21 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - JST.JSTAGE/jts/31.169 [pii]
AID - 10.2131/jts.31.169 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2006 May;31(2):169-75. doi: 10.2131/jts.31.169.