PMID- 16773428
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20181113
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 290
IP  - 1-2
DP  - 2006 Oct
TI  - Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes 
      with or without diabetic pedigree in Chinese.
PG  - 199-204
AB  - OBJECTIVE: Based on onset-age stratified analysis may be useful to determine the 
      association of NeuroD1-Ala45Thr variation with susceptibility to genetic 
      heterogeneous type 2 diabetes mellitus (T2DM), we investigated the Ala45Thr 
      variation in unrelated early-onset and late-onset T2DM with or without diabetic 
      pedigree and unrelated non-diabetic control subjects in Chinese. METHODS: 175 
      early-onset and 194 late-onset type 2 diabetic patients were further divided into 
      two subgroups according to with or without diabetic pedigree respectively. This 
      NeuroD1-Ala45Thr variation were screened by PCR-direct sequencing in above 369 
      type 2 diabetic patients and 87 unrelated non-diabetic control subjects. We then 
      compared the distribution of the Ala45Thr variation among the groups, searching 
      for the predictive trends. RESULTS: Frequencies of the variant (AA + GA genotype) 
      in early-onset T2DM are obviously elevated, especially among diabetic pedigree 
      subjects when compared to non-diabetic controls (p= 0.003) and late-onset T2DM 
      subjects (p = 0.014). However, no significant differences were observed between 
      late-onset T2DM with or without diabetic pedigree and non-diabetic control 
      subjects. CONCLUSIONS: Our results suggest that 1) the NeuroD1-Ala45Thr variation 
      may itself have an important role in susceptibility to or be in disequilibrium 
      with early-onset T2DM in Chinese; 2) the Ala45Thr may affect the onset pattern of 
      T2DM, i.e., early-onset but not late-onset T2DM in Chinese; and 3) onset-age 
      stratified analysis may be useful to determine the association of 
      NeuroD1-Ala45Thr variation with susceptibility to genetic heterogeneous T2DM in 
      Chinese.
FAU - Liu, Limei
AU  - Liu L
AD  - Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai 
      Jiaotong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 
      200233, China. liulimei2001@hotmail.com
FAU - Jia, Weiping
AU  - Jia W
FAU - Zheng, Taishan
AU  - Zheng T
FAU - Li, Ming
AU  - Li M
FAU - Lu, Huijuan
AU  - Lu H
FAU - Xiang, Kunsan
AU  - Xiang K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060614
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (NEUROD1 protein, human)
RN  - 2ZD004190S (Threonine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alanine
MH  - *Amino Acid Substitution
MH  - Basic Helix-Loop-Helix Transcription Factors/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics/physiopathology
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Middle Aged
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - Threonine
EDAT- 2006/06/15 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/06/15 09:00
PHST- 2005/09/30 00:00 [received]
PHST- 2006/04/21 00:00 [accepted]
PHST- 2006/06/15 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/06/15 09:00 [entrez]
AID - 10.1007/s11010-006-9217-4 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2006 Oct;290(1-2):199-204. doi: 10.1007/s11010-006-9217-4. Epub 
      2006 Jun 14.