PMID- 16776750
OWN - NLM
STAT- MEDLINE
DCOM- 20070329
LR  - 20171116
IS  - 1462-8902 (Print)
IS  - 1462-8902 (Linking)
VI  - 8
IP  - 4
DP  - 2006 Jul
TI  - Relative androgen deficiency in relation to obesity and metabolic status in older 
      men.
PG  - 429-35
AB  - BACKGROUND: Although androgen deficiency in men has been linked with obesity and 
      the metabolic syndrome, whether it predisposes to, or is a consequence of, type 2 
      diabetes mellitus (T2DM) is still unclear. OBJECTIVE: To determine the 
      relationship between plasma androgen levels, obesity, metabolic status and T2DM 
      in men of 70 years or older. DESIGN AND METHODS: A sample of 195 men from the 
      Australian Longitudinal Study of Ageing with a mean age of 76.2 +/- 0.3 years 
      were followed up for 8 years. Total testosterone (TT), fasting plasma glucose 
      (FPG), urate, serum creatinine, total cholesterol (TC), HDL cholesterol (HDL-C), 
      LDL cholesterol (LDL-C), triglycerides (TG), blood pressure (BP), body mass index 
      (BMI), waist circumference (WC) and diabetic status were assessed at baseline. 
      Self-reported diabetic status was obtained after 8 years. Metabolic syndrome was 
      diagnosed based on the Third National Cholesterol Education Program Adult 
      Treatment Panel clinical criteria. RESULTS: TT levels were lower in diabetic men 
      compared with non-diabetic men (12.1 +/- 0.7 vs. 14.2 +/- 0.4 nmol/l, p = 0.026). 
      TT levels in healthy, non-diabetic men over 80 years of age were lower (11.9 +/- 
      0.8 vs. 15.0 +/- 0.5 nmol/l, p = 0.002) than TT levels in those aged 70-79 years, 
      inversely related to BMI (r = -0.26, p = 0.001), WC (r = -0.30, p < 0.001) and TG 
      (r = -0.22, p = 0.005) and positively related to LDL-C (r = 0.25, p = 0.002). Men 
      with the metabolic syndrome had significantly lower levels of TT and HDL-C, and 
      higher values of BP, FPG, TG, BMI and WC, compared with those without. However, 
      no significant difference in plasma TT levels was noted between men with incident 
      T2Dm and healthy men. Stepwise linear regression analysis revealed that only 
      LDL-C and WC related significantly to the variance of TT. Multiple logistic 
      regression revealed FPG to be the only independent predictor of incident diabetes 
      (odds ratio = 60.2, p = 0.003). CONCLUSIONS: Testosterone levels continue to 
      decline even in healthy men over the age of 80 years. Although TT levels were 
      inversely related to visceral obesity and several components of the metabolic 
      syndrome, our data do not support a predictive or causative role for decreasing 
      TT levels in the development of incident T2Dm. Androgen deficiency is consequent 
      upon, rather than a cause of, poor metabolic status.
FAU - Chen, R Y T
AU  - Chen RY
AD  - Department of Medicine, University of Adelaide, Adelaide, South Australia, 
      Australia. chenyt10@hotmail.com
FAU - Wittert, G A
AU  - Wittert GA
FAU - Andrews, G R
AU  - Andrews GR
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Obes Metab
JT  - Diabetes, obesity & metabolism
JID - 100883645
RN  - 0 (Lipids)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood
MH  - Body Constitution
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Humans
MH  - Hypogonadism/*etiology
MH  - Lipids/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Metabolic Syndrome/blood/*complications
MH  - Obesity/blood/*complications
MH  - Testosterone/blood
EDAT- 2006/06/17 09:00
MHDA- 2007/03/30 09:00
CRDT- 2006/06/17 09:00
PHST- 2006/06/17 09:00 [pubmed]
PHST- 2007/03/30 09:00 [medline]
PHST- 2006/06/17 09:00 [entrez]
AID - DOM532 [pii]
AID - 10.1111/j.1463-1326.2005.00532.x [doi]
PST - ppublish
SO  - Diabetes Obes Metab. 2006 Jul;8(4):429-35. doi: 10.1111/j.1463-1326.2005.00532.x.