PMID- 16777310
OWN - NLM
STAT- MEDLINE
DCOM- 20061031
LR  - 20161124
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 30
IP  - 7
DP  - 2006 Sep 30
TI  - Regional cerebral blood flow changes associated with interoceptive awareness in 
      the recovery process of anorexia nervosa.
PG  - 1265-70
AB  - BACKGROUND: An abnormality in regional cerebral blood flow (rCBF) in anorexia 
      nervosa (AN) patients has been reported. There are very few studies that have 
      investigated the rCBF changes in the recovery process of AN. METHODS: For eight 
      female AN patients, we performed (123)I-IMP single photon emission computed 
      tomography (SPECT) and four psychological assessments (Eating Disorder Inventory 
      (EDI), Eating Attitude Test (EAT), Self-Rating Depression Scale (SDS) and 
      State-Trait Anxiety Inventory (STAI)) both before and after inpatient-behavioral 
      therapy. SPECT images were analyzed using statistical parametric mapping 
      software. We also performed correlational analysis between rCBF and clinical 
      variables. RESULTS: Following treatment, the patients showed significant body 
      weight recovery. They showed significant improvement in EAT, SDS, STAI and a 
      subscale of EDI - interoceptive awareness (IA) - but not in total EDI or other 
      EDI subscales. Significant rCBF increases were observed in the precuneus, 
      posterior cingulate cortex (PCC), right dorsolateral prefrontal cortex (DLPFC), 
      anterior cingulate cortex (ACC) and medial prefrontal cortex (MPFC) by the 
      treatment. Significant correlation was observed between rCBF of right DLPFC and 
      IA score before treatment. CONCLUSIONS: Changes of rCBF in right DLPFC, ACC, 
      MPFC, PCC and precuneus were related to the AN recovery process and might be 
      associated with improvement of IA following treatment.
FAU - Matsumoto, Ryohei
AU  - Matsumoto R
AD  - Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural 
      University of Medicine, Kyoto 602-8566, Japan. rmat@nirs.go.jp <rmat@nirs.go.jp>
FAU - Kitabayashi, Yurinosuke
AU  - Kitabayashi Y
FAU - Narumoto, Jin
AU  - Narumoto J
FAU - Wada, Yoshihisa
AU  - Wada Y
FAU - Okamoto, Akiko
AU  - Okamoto A
FAU - Ushijima, Yo
AU  - Ushijima Y
FAU - Yokoyama, Chihiro
AU  - Yokoyama C
FAU - Yamashita, Tatsuhisa
AU  - Yamashita T
FAU - Takahashi, Hidehiko
AU  - Takahashi H
FAU - Yasuno, Fumihiko
AU  - Yasuno F
FAU - Suhara, Tetsuya
AU  - Suhara T
FAU - Fukui, Kenji
AU  - Fukui K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060614
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Iodine Isotopes)
RN  - 131-99-7 (Inosine Monophosphate)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine/pharmacokinetics
MH  - Anorexia Nervosa/diagnostic imaging/*physiopathology
MH  - Awareness/*physiology
MH  - Brain/*blood supply/diagnostic imaging/drug effects
MH  - Female
MH  - Humans
MH  - Inosine Monophosphate/metabolism
MH  - Iodine Isotopes/pharmacokinetics
MH  - Psychological Tests/statistics & numerical data
MH  - Recovery of Function/*physiology
MH  - Regional Blood Flow/physiology
MH  - Statistics as Topic
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2006/06/17 09:00
MHDA- 2006/11/01 09:00
CRDT- 2006/06/17 09:00
PHST- 2006/01/12 00:00 [received]
PHST- 2006/03/13 00:00 [revised]
PHST- 2006/03/30 00:00 [accepted]
PHST- 2006/06/17 09:00 [pubmed]
PHST- 2006/11/01 09:00 [medline]
PHST- 2006/06/17 09:00 [entrez]
AID - S0278-5846(06)00174-6 [pii]
AID - 10.1016/j.pnpbp.2006.03.042 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2006 Sep 30;30(7):1265-70. doi: 
      10.1016/j.pnpbp.2006.03.042. Epub 2006 Jun 14.