PMID- 1677811
OWN - NLM
STAT- MEDLINE
DCOM- 19910911
LR  - 20190907
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 33
IP  - 3
DP  - 1991 Mar
TI  - Characterization of the murine Hox-2.3 promoter: involvement of the transcription 
      factor USF (MLTF).
PG  - 179-90
AB  - The murine homeobox-containing gene Hox-2.3 contains a basal promoter in a 210-bp 
      region upstream of the transcription start site. In vitro studies of DNA-protein 
      interactions in this region, and in a 1.3-kb upstream region which is known to 
      play a role in tissue specific expression in vivo, led to the identification of 
      DNA elements interacting with nuclear proteins from embryocarcinoma cells. Among 
      the factors binding to the basal promoter is the upstream stimulating factor 
      (USF), also known as major late transcription factor (MLTF). A single point 
      mutation in its binding site abolishes binding in vitro and leads to 50% 
      reduction of the transcriptional activity as measured in receptor gene 
      experiments, showing that it is an activator of Hox-2.3 expression.
FAU - Zwartkruis, F
AU  - Zwartkruis F
AD  - Hubrecht Laboratory, Netherlands Institute for Developmental Biology Utrecht.
FAU - Hoeijmakers, T
AU  - Hoeijmakers T
FAU - Deschamps, J
AU  - Deschamps J
FAU - Meijlink, F
AU  - Meijlink F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Upstream Stimulatory Factors)
RN  - 0 (Usf1 protein, mouse)
RN  - EC 3.1.- (Deoxyribonucleases)
RN  - EC 3.1.- (Exodeoxyribonucleases)
RN  - EC 3.1.11.2 (exodeoxyribonuclease III)
SB  - IM
GS  - Hox-2.3
MH  - Animals
MH  - Base Sequence
MH  - DNA-Binding Proteins/analysis
MH  - Deoxyribonucleases/analysis
MH  - Exodeoxyribonucleases/antagonists & inhibitors
MH  - Genes, Homeobox/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Promoter Regions, Genetic/*genetics
MH  - Transcription Factors/*physiology
MH  - Upstream Stimulatory Factors
EDAT- 1991/03/01 00:00
MHDA- 1991/03/01 00:01
CRDT- 1991/03/01 00:00
PHST- 1991/03/01 00:00 [pubmed]
PHST- 1991/03/01 00:01 [medline]
PHST- 1991/03/01 00:00 [entrez]
AID - 0925-4773(91)90026-3 [pii]
AID - 10.1016/0925-4773(91)90026-3 [doi]
PST - ppublish
SO  - Mech Dev. 1991 Mar;33(3):179-90. doi: 10.1016/0925-4773(91)90026-3.