PMID- 16779004
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20181113
IS  - 1942-597X (Electronic)
IS  - 1559-4076 (Linking)
VI  - 2005
DP  - 2005
TI  - Qualitative pharmacokinetic modeling of drugs.
PG  - 71-5
AB  - We hypothesize that a representation of drug-drug interactions (DDIs) based on 
      physiologic, pharmacokinetic (PK) and pharmacodynamic (PD) mechanisms will 
      provide more accurate and useful information to clinicians than current 
      approaches that simply tabulate and index pairwise interactions of drugs. This 
      paper explores the strengths, weaknesses, and difficulties of modeling drug 
      mechanisms and reports on our initial work designing and implementing a drug KB 
      based on qualitative pharmacokinetic mechanisms.
FAU - Boyce, Richard
AU  - Boyce R
AD  - Department of Biomedical and Health Informatics, University of Washington, USA.
FAU - Collins, Carol
AU  - Collins C
FAU - Horn, John
AU  - Horn J
FAU - Kalet, Ira J
AU  - Kalet IJ
LA  - eng
GR  - T15 LM007442/LM/NLM NIH HHS/United States
GR  - T15 LM07442/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - AMIA Annu Symp Proc
JT  - AMIA ... Annual Symposium proceedings. AMIA Symposium
JID - 101209213
SB  - IM
MH  - Dose-Response Relationship, Drug
MH  - *Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Knowledge Bases
MH  - *Models, Biological
MH  - *Pharmacokinetics
MH  - *Pharmacology
MH  - Pharmacology, Clinical/methods
PMC - PMC1560821
EDAT- 2006/06/17 09:00
MHDA- 2007/02/16 09:00
PMCR- 2005/01/01
CRDT- 2006/06/17 09:00
PHST- 2006/06/17 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/06/17 09:00 [entrez]
PHST- 2005/01/01 00:00 [pmc-release]
AID - 58917 [pii]
AID - amia2005_0071 [pii]
PST - ppublish
SO  - AMIA Annu Symp Proc. 2005;2005:71-5.