PMID- 16779825
OWN - NLM
STAT- MEDLINE
DCOM- 20060913
LR  - 20151119
IS  - 0736-0266 (Print)
IS  - 0736-0266 (Linking)
VI  - 24
IP  - 8
DP  - 2006 Aug
TI  - The entrapment of corrosion products from CoCr implant alloys in the deposits of 
      calcium phosphate: a comparison of serum, synovial fluid, albumin, EDTA, and 
      water.
PG  - 1587-96
AB  - Physical wear of orthopedic implants is inevitable. CoCr alloy samples, typically 
      used in joint reconstruction, corrode rapidly after removal of the protective 
      oxide layer. The behavior of CoCr pellets immersed in human serum, foetal bovine 
      serum (FBS), synovial fluid, albumin in phosphate-buffered saline (PBS), EDTA in 
      PBS, and water were studied using X-ray Photoelectron Spectroscopy (XPS) and 
      Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS). The difference in the 
      corrosive nature of human serum, water, albumin in PBS and synovial fluid after 5 
      days of immersion was highlighted by the oxide layer, which was respectively 15, 
      3.5, 1.5, and 1.5 nm thick. The thickness of an additional calcium phosphate 
      deposit from human serum and synovial fluid was 40 and 2 nm, respectively. Co and 
      Cr ions migrated from the bulk metal surface and were trapped in this deposit by 
      the phosphate anion. This may account for the composition of wear debris from 
      CoCr orthopedic implants, which is known to consist predominantly of 
      hydroxy-phosphate compounds. Known components of synovial fluid including 
      proteoglycans, pyrophosphates, phospholipids, lubricin, and superficial zone 
      protein (SZP), have been identified as possible causes for the lack of 
      significant calcium phosphate deposition in this environment. Circulation of 
      these compounds around the whole implant may inhibit calcium phosphate 
      deposition.
FAU - Lewis, A C
AU  - Lewis AC
AD  - Interface Analysis Centre, University of Bristol, 121 St. Michael's Hill, 
      Bristol, BS2 8BS, UK. andrewclewis@postmaster.co.uk
FAU - Kilburn, M R
AU  - Kilburn MR
FAU - Heard, P J
AU  - Heard PJ
FAU - Scott, T B
AU  - Scott TB
FAU - Hallam, K R
AU  - Hallam KR
FAU - Allen, G C
AU  - Allen GC
FAU - Learmonth, I D
AU  - Learmonth ID
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic 
      Research Society
JID - 8404726
RN  - 0 (Albumins)
RN  - 0 (Buffers)
RN  - 0 (Calcium Phosphates)
RN  - 0 (Chromium Alloys)
RN  - 059QF0KO0R (Water)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 97Z1WI3NDX (calcium phosphate)
RN  - 9G34HU7RV0 (Edetic Acid)
SB  - IM
MH  - Albumins/chemistry
MH  - Animals
MH  - Buffers
MH  - Calcium Phosphates/*chemistry
MH  - Cattle
MH  - Chromium Alloys/*chemistry
MH  - Corrosion
MH  - Edetic Acid/chemistry
MH  - Fetal Blood/*chemistry
MH  - Humans
MH  - In Vitro Techniques
MH  - *Prosthesis Failure
MH  - Sodium Chloride
MH  - Spectrometry, Mass, Secondary Ion
MH  - Spectrometry, X-Ray Emission
MH  - Stress, Mechanical
MH  - Synovial Fluid/*chemistry
MH  - Water/chemistry
EDAT- 2006/06/17 09:00
MHDA- 2006/09/14 09:00
CRDT- 2006/06/17 09:00
PHST- 2006/06/17 09:00 [pubmed]
PHST- 2006/09/14 09:00 [medline]
PHST- 2006/06/17 09:00 [entrez]
AID - 10.1002/jor.20198 [doi]
PST - ppublish
SO  - J Orthop Res. 2006 Aug;24(8):1587-96. doi: 10.1002/jor.20198.