PMID- 16780257
OWN - NLM
STAT- MEDLINE
DCOM- 20060912
LR  - 20161124
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 20
IP  - 117
DP  - 2006 Mar
TI  - [NT-proBNP and echocardiography for long-term left ventricular function 
      assessment after acute myocardial infarction treated with primary angioplasty].
PG  - 289-92
AB  - At present, primary angioplasty (PTCA) is preferred reperfusion treatment for 
      acute ST elevation myocardial infarction (STEMI). Risk stratification after STEMI 
      includes the evaluation of left ventricular (LV) function. B-type natriuretic 
      peptide testing emerged as a potential marker of LV function and prognosis after 
      STEMI. AIM: The objective was long-term echocardiographic assessment of LV 
      systolic and diastolic function in patients with STEMI who underwent PTCA and to 
      evaluation of the relationship between NT-proBNP plasma levels and LV function. 
      We assessed the value of NT-proBNP in prediction of LV dysfunction after STEMI 
      treated with PTCA. MATERIAL AND METHODS: A series of 98 patients (pts) (75 males, 
      23 females age from 50.0 to 63.0, mean age 55.0), treated successfully with PTCA 
      in acute phase of STEMI were included in this study. NT-proBNP plasma levels were 
      assessed just before PTCA (BNP-bsl) and at 6 month follow-up (BNP-6m). 
      Transthoracic echocardiography (TTE) was performed at discharge(dc) and at 6 
      months follow-up (6m). The indices of LV systolic function (LVSF) (LV ejection 
      fraction-EF, wall motion score index-WMSI), LV diastolic function (LVDF) (peak 
      velocity of early (E) and late (A) transmitral flow, E-wave deceleration time 
      (DT), isovolumic relaxation time (IVRT)) and global LV function (Tei index- 
      calculated as a sum of isovolumetric contraction time and IVRT divided by the 
      ejection time) were estimated. RESULTS: At 6 month echocardiographic follow-up we 
      observed the significant improvement of LVSF (the increase of EF (p < 0.0027), 
      the decrease of WMSI (p < 0.0005)) and the deterioration of LVDF (the decrease of 
      E/A (p < 0015), the increase of IVRT (p < 0085)). A negative correlation between 
      BNP-bsl and EF-6m (Rs = -0.2877, p < 0.0072) and BNP-6m and EF-6m (Rs = 0.4125, p 
      < 0.0001) were observed. Multivariate analysis identified BNP-bsl and CPK max 
      during acute phase of STEMI as negative and EF-dc as positive significant, 
      independent predictors of EF-6m. CONCLUSIONS: The significant improvement of LV 
      systolic function and LV abnormal relaxation were observed at 6 month follow-up 
      in patients with acute STEMI treated with primary angioplasty. Baseline NT-proBNP 
      plasma level, CPK max plasma level during acute phase of STEMI and 
      echocardiographic LV systolic function indices at discharge are significant and 
      independent predictors of LV systolic function in long-term follow up. Increasing 
      NT-proBNP plasma level at 6 month after STEMI treated with PTCA has a good 
      performance in detecting of LV systolic function deterioration in long-term 
      follow-up.
FAU - Swiatkiewicz, Iwona
AU  - Swiatkiewicz I
AD  - Uniwersytet Mikolaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra 
      i Klinika Kardiologii i Chorob Wewnetrznych. i.swiat@wp.pl
FAU - Grubecki, Arkadiusz
AU  - Grubecki A
FAU - Kozinski, Marek
AU  - Kozinski M
FAU - Fabiszak, Tomasz
AU  - Fabiszak T
FAU - Bialoszynski, Tomasz
AU  - Bialoszynski T
FAU - Sukiennik, Adam
AU  - Sukiennik A
FAU - Kubica, Jacek
AU  - Kubica J
LA  - pol
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
TT  - Przydatnosc echokardiografii oraz oznaczania stezenia NT-proBNP w osoczu do 
      odleglej oceny funkcji lewej komory u chorych z ostrym zawalem serca leczonych 
      pierwotna angioplastyka wiencowa.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Angioplasty, Balloon, Coronary/methods
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*diagnosis/physiopathology/*therapy
MH  - Myocardial Revascularization/methods
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Ventricular Dysfunction, Left/*blood/*diagnostic imaging/etiology/physiopathology
EDAT- 2006/06/20 09:00
MHDA- 2006/09/13 09:00
CRDT- 2006/06/20 09:00
PHST- 2006/06/20 09:00 [pubmed]
PHST- 2006/09/13 09:00 [medline]
PHST- 2006/06/20 09:00 [entrez]
PST - ppublish
SO  - Pol Merkur Lekarski. 2006 Mar;20(117):289-92.