PMID- 16783370
OWN - NLM
STAT- MEDLINE
DCOM- 20060905
LR  - 20181201
IS  - 1097-6256 (Print)
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 9
IP  - 7
DP  - 2006 Jul
TI  - Amygdala BDNF signaling is required for consolidation but not encoding of 
      extinction.
PG  - 870-2
AB  - Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B 
      receptor (TrkB) is thought to be a critical mediator of learning. As there are no 
      available selective antagonists of TrkB, we used a lentivirus encoding a 
      dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction 
      of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session 
      extinction, their retention of extinction was impaired, suggesting that amygdala 
      TrkB activation is required for the consolidation of stable extinction memories.
FAU - Chhatwal, Jasmeer P
AU  - Chhatwal JP
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, Georgia 30322, USA.
FAU - Stanek-Rattiner, Lisa
AU  - Stanek-Rattiner L
FAU - Davis, Michael
AU  - Davis M
FAU - Ressler, Kerry J
AU  - Ressler KJ
LA  - eng
GR  - R01 MH047840/MH/NIMH NIH HHS/United States
GR  - K01 MH069884-02/MH/NIMH NIH HHS/United States
GR  - T32 GM008169/GM/NIGMS NIH HHS/United States
GR  - MH069884/MH/NIMH NIH HHS/United States
GR  - MH47840/MH/NIMH NIH HHS/United States
GR  - R37 MH047840/MH/NIMH NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - K01 MH069884-01/MH/NIMH NIH HHS/United States
GR  - R01 DA019624-01A2/DA/NIDA NIH HHS/United States
GR  - K01 MH069884-03/MH/NIMH NIH HHS/United States
GR  - K01 MH069884/MH/NIMH NIH HHS/United States
GR  - P51 RR000165-460189/RR/NCRR NIH HHS/United States
GR  - P51RR000165/RR/NCRR NIH HHS/United States
GR  - R01 DA019624/DA/NIDA NIH HHS/United States
GR  - P51 RR000165-450216/RR/NCRR NIH HHS/United States
GR  - F30 MH070218/MH/NIMH NIH HHS/United States
GR  - MH070218/MH/NIMH NIH HHS/United States
GR  - P51 RR000165-457288/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060618
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cannabinoid Receptor Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 0 (RNA, Messenger)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - RML78EN3XE (Rimonabant)
SB  - IM
MH  - Amygdala/*metabolism
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cannabinoid Receptor Antagonists
MH  - Conditioning, Classical/drug effects/*physiology
MH  - Extinction, Psychological/physiology
MH  - Gene Expression/drug effects/physiology
MH  - Genetic Vectors/physiology
MH  - Green Fluorescent Proteins/biosynthesis
MH  - Immunohistochemistry/methods
MH  - Lentivirus/physiology
MH  - Male
MH  - Piperidines/pharmacology
MH  - Pyrazoles/pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/physiology
MH  - Reflex, Startle/drug effects/physiology
MH  - Rimonabant
MH  - Signal Transduction/drug effects/*physiology
MH  - Time Factors
PMC - PMC2562628
MID - NIHMS55890
EDAT- 2006/06/20 09:00
MHDA- 2006/09/06 09:00
PMCR- 2008/10/07
CRDT- 2006/06/20 09:00
PHST- 2006/04/28 00:00 [received]
PHST- 2006/05/18 00:00 [accepted]
PHST- 2006/06/20 09:00 [pubmed]
PHST- 2006/09/06 09:00 [medline]
PHST- 2006/06/20 09:00 [entrez]
PHST- 2008/10/07 00:00 [pmc-release]
AID - nn1718 [pii]
AID - 10.1038/nn1718 [doi]
PST - ppublish
SO  - Nat Neurosci. 2006 Jul;9(7):870-2. doi: 10.1038/nn1718. Epub 2006 Jun 18.