PMID- 16783451
OWN - NLM
STAT- MEDLINE
DCOM- 20061010
LR  - 20220410
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 39
IP  - 3
DP  - 2006 Jun
TI  - Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil 
      count with the severity of childhood perennial allergic rhinitis.
PG  - 212-8
AB  - BACKGROUND AND PURPOSE: Elevated levels of serum total immunoglobulin E (IgE), 
      serum allergen-specific IgE, serum eosinophil cationic protein (ECP), blood 
      eosinophil count and nasal eosinophil count are considered to be associated with 
      allergic rhinitis (AR), but the relationships between these allergic inflammatory 
      markers and the clinical severity of AR remain controversial. This study aimed to 
      clarify these relationships. METHODS: 186 children aged 2 to 12 years old were 
      selected, including 160 with perennial AR (PAR) and 26 with non-AR as controls. 
      The total nasal symptom score was calculated for each patient from a 
      questionnaire and correlated with data on serum total IgE, serum 
      allergen-specific IgE, serum ECP, and eosinophil count in blood and nasal smear. 
      RESULTS: Levels of all allergic inflammatory markers in children with PAR were 
      significantly different from those in non-allergic children, except for serum 
      ECP. All of the markers were related to the severity of PAR in bivariate 
      correlation analysis. On multiple linear regression analysis, however, only nasal 
      eosinophil count (p<0.001) and serum allergen-specific IgE (p=0.005) were 
      independent predictors. CONCLUSION: These results suggest that nasal eosinophil 
      count, an organ-specific allergic inflammatory marker, and serum 
      allergen-specific IgE, a systemic allergic inflammatory marker, are correlated 
      with the severity of PAR in children.
FAU - Chen, Shuei Tu
AU  - Chen ST
AD  - Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung 
      Shan Medical University Hospital, Taichung, Taiwan.
FAU - Sun, Hai Lun
AU  - Sun HL
FAU - Lu, Ko Hsiu
AU  - Lu KH
FAU - Lue, Ko Huang
AU  - Lue KH
FAU - Chou, Ming Chih
AU  - Chou MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Eosinophil Cationic Protein/*immunology
MH  - Eosinophils/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Leukocyte Count
MH  - Male
MH  - Mites/immunology
MH  - Rhinitis, Allergic, Perennial/blood/*immunology
EDAT- 2006/06/20 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/06/20 09:00
PHST- 2006/06/20 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/06/20 09:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2006 Jun;39(3):212-8.