PMID- 16784955
OWN - NLM
STAT- MEDLINE
DCOM- 20060809
LR  - 20220311
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 55
IP  - 7
DP  - 2006 Jul
TI  - Serum brain-derived neurotrophic factor level is increased and associated with 
      obesity in newly diagnosed female patients with type 2 diabetes mellitus.
PG  - 852-7
AB  - Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) 
      played a role in the eating behavior and glucose and lipid metabolism. In this 
      study we measured the serum BDNF levels in newly diagnosed female patients with 
      type 2 diabetes mellitus (n = 24, aged 34-59 years) and female subjects with 
      normal glucose tolerance (n = 7, aged 34-56 years). The serum BDNF level was 
      found to significantly increase in diabetic patients in comparison to that in 
      healthy subjects (P < .05). In these patients, the serum BDNF level showed 
      positive correlation with the body mass index (r = 0.535, P < .01), the 
      percentage of body fat (r = 0.552, P < .01), the subcutaneous fat area based on 
      computed tomography scan (r = 0.480, P < .05), the triglyceride level (r = 0.470, 
      P < .05), the fasting blood glucose level (r = 0.437, P < .05), and the 
      homeostasis model assessment of insulin resistance score (r = 0.506, P < .05), 
      whereas it showed a negative correlation with age (r = -0.486, P < .05). The 
      partial correlation coefficients adjusted by age showed significant differences 
      regarding the body mass index (r = 0.423, P < .05), percentage of body fat (r = 
      0.504, P < .05), and triglyceride level (r = 0.426, P < .05). These results 
      provide the first evidence that an increased BDNF is associated with a prevalence 
      of type 2 diabetes mellitus. In addition, the BDNF is related to the total and 
      abdominal subcutaneous fat mass and energy metabolism in the newly diagnosed 
      female patients with type 2 diabetes mellitus.
FAU - Suwa, Masataka
AU  - Suwa M
AD  - Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816-8580, Japan. 
      suwa-m@students.ihs.kyushu-u.ac.jp
FAU - Kishimoto, Hiroyo
AU  - Kishimoto H
FAU - Nofuji, Yu
AU  - Nofuji Y
FAU - Nakano, Hiroshi
AU  - Nakano H
FAU - Sasaki, Haruka
AU  - Sasaki H
FAU - Radak, Zsolt
AU  - Radak Z
FAU - Kumagai, Shuzo
AU  - Kumagai S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics/physiology
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Middle Aged
MH  - Obesity/*blood
MH  - RNA, Messenger/analysis
EDAT- 2006/06/21 09:00
MHDA- 2006/08/10 09:00
CRDT- 2006/06/21 09:00
PHST- 2005/07/29 00:00 [received]
PHST- 2006/02/16 00:00 [accepted]
PHST- 2006/06/21 09:00 [pubmed]
PHST- 2006/08/10 09:00 [medline]
PHST- 2006/06/21 09:00 [entrez]
AID - S0026-0495(06)00067-9 [pii]
AID - 10.1016/j.metabol.2006.02.012 [doi]
PST - ppublish
SO  - Metabolism. 2006 Jul;55(7):852-7. doi: 10.1016/j.metabol.2006.02.012.