PMID- 16785316
OWN - NLM
STAT- MEDLINE
DCOM- 20061010
LR  - 20161114
IS  - 0022-3565 (Print)
IS  - 0022-3565 (Linking)
VI  - 318
IP  - 3
DP  - 2006 Sep
TI  - Neonatal intrahippocampal glycoprotein 120 injection: the role of dopaminergic 
      alterations in prepulse inhibition in adult rats.
PG  - 1352-8
AB  - Following neonatal hippocampal administration on postnatal day 1, the 
      dose-response effects of the human immunodeficiency virus 1 protein glycoprotein 
      120 (gp120) were studied in vivo on prepulse inhibition (PPI) in adulthood. 
      Furthermore, the role of dopaminergic alterations was examined as a 
      within-subject factor. Using a randomized-block design, male and female pups of 
      eight Sprague-Dawley litters were injected bilaterally with either vehicle (1 
      microl volume) or gp120 (1.29, 12.9, or 129 ng/microl). At 9 months of age, rats 
      were injected s.c. with saline (SAL) (0.1 ml/kg) and tested on preattentive 
      processes, as indexed by sensorimotor gating. Sensorimotor gating was measured by 
      PPI of the auditory startle response (ASR) [interstimulus intervals (ISIs) of 0, 
      8, 40, 80, 120, and 4000 ms, six trial blocks, Latin square design]. One month 
      later, the animals were treated with a D(1)/D(2) agonist, apomorphine (APO) (0.1 
      mg/kg) and again tested for PPI. A significant attenuation of the baseline ASR by 
      APO was noted. No significant effects were noted on control ASR trials (ISIs, 0 
      and 4000 ms). For the SAL condition, response inhibition was significantly 
      reduced as a function of gp120 dose, and the inflection of the inhibition curve 
      was significantly altered for the high-gp120 dose-treated animals. A gp120 
      treatment x APO drug interaction was evident on amplitude, but not latency, of 
      the response inhibition, with an enhanced inhibition in the APO condition, 
      collapsed across ISIs (08-120 ms) as the neonatal-injected gp120 dose increased. 
      Use of APO to probe integrity of the dopaminergic system suggests long-lasting 
      alterations in neuronal responses consequent to neonatal gp120 exposure.
FAU - Fitting, Sylvia
AU  - Fitting S
AD  - Department of Psychology, University of South Carolina, Columbia, SC 29208, USA. 
      fitting@sc.edu
FAU - Booze, Rosemarie M
AU  - Booze RM
FAU - Mactutus, Charles F
AU  - Mactutus CF
LA  - eng
GR  - R01 HD043680/HD/NICHD NIH HHS/United States
GR  - DA014401/DA/NIDA NIH HHS/United States
GR  - DA013137/DA/NIDA NIH HHS/United States
GR  - R01 DA013137-06A1/DA/NIDA NIH HHS/United States
GR  - R01 DA013137/DA/NIDA NIH HHS/United States
GR  - HD043680/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060619
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (HIV Envelope Protein gp120)
RN  - 0 (Receptors, Dopamine D1)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Apomorphine/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - HIV Envelope Protein gp120/*toxicity
MH  - HIV-1/pathogenicity
MH  - Hippocampus/*drug effects
MH  - N-Methylaspartate/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D1/*drug effects/physiology
MH  - Reflex, Startle/*drug effects
EDAT- 2006/06/21 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/06/21 09:00
PHST- 2006/06/21 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/06/21 09:00 [entrez]
AID - jpet.106.105742 [pii]
AID - 10.1124/jpet.106.105742 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2006 Sep;318(3):1352-8. doi: 10.1124/jpet.106.105742. Epub 
      2006 Jun 19.