PMID- 1678681
OWN - NLM
STAT- MEDLINE
DCOM- 19910925
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 68
IP  - 6
DP  - 1991 Sep 15
TI  - Surgical pathology of gastrinoma. Site, size, multicentricity, association with 
      multiple endocrine neoplasia type 1, and malignancy.
PG  - 1329-34
AB  - Specimens from the pancreas and duodenum of 26 patients with sporadic 
      Zollinger-Ellison syndrome (ZES) and 18 patients with multiple endocrine 
      neoplasia type 1 (MEN-1) and hypergastrinemia (17 with ZES) were screened 
      immunocytochemically for gastrinomas. Location, size, multicentricity, and 
      malignancy of the gastrinomas were evaluated. The MEN-1 patients had gastrinomas 
      in the duodenum (nine of 18), pancreas (one of 18), and periduodenal lymph nodes 
      (two of 18). No gastrinoma was identified in six patients. Most duodenal 
      gastrinomas were multiple (five of nine) and smaller than 0.6 cm (six of nine). 
      Lymph node metastases were present in eight of 12 patients. All 26 patients with 
      sporadic ZES had a solitary gastrinoma; 14 were found in the pancreas and had a 
      diameter greater than 2 cm. Ten patients had a duodenal gastrinoma, two with a 
      diameter less than 0.6 cm. In two patients, only periduodenal "lymph node 
      gastrinomas" were detected. Eighteen of the sporadic gastrinomas were malignant. 
      These results suggest that duodenal location and multicentricity of gastrinomas 
      are associated with the MEN-1 syndrome, and solitary gastrinomas, either in the 
      pancreas or the duodenum, are predominantly seen in sporadic ZES.
FAU - Donow, C
AU  - Donow C
AD  - Department of Pathology, Academic Hospital Jette, Free University of Brussels, 
      Belgium.
FAU - Pipeleers-Marichal, M
AU  - Pipeleers-Marichal M
FAU - Schroder, S
AU  - Schroder S
FAU - Stamm, B
AU  - Stamm B
FAU - Heitz, P U
AU  - Heitz PU
FAU - Kloppel, G
AU  - Kloppel G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Gastrins)
SB  - IM
MH  - Duodenal Neoplasms/*pathology
MH  - Gastrinoma/*pathology/secondary
MH  - Gastrins/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/secondary
MH  - Lymphatic Metastasis
MH  - Multiple Endocrine Neoplasia/*pathology
MH  - Pancreatic Neoplasms/*pathology
MH  - Zollinger-Ellison Syndrome/*pathology
EDAT- 1991/09/15 00:00
MHDA- 1991/09/15 00:01
CRDT- 1991/09/15 00:00
PHST- 1991/09/15 00:00 [pubmed]
PHST- 1991/09/15 00:01 [medline]
PHST- 1991/09/15 00:00 [entrez]
AID - 10.1002/1097-0142(19910915)68:6<1329::aid-cncr2820680624>3.0.co;2-7 [doi]
PST - ppublish
SO  - Cancer. 1991 Sep 15;68(6):1329-34. doi: 
      10.1002/1097-0142(19910915)68:6<1329::aid-cncr2820680624>3.0.co;2-7.