PMID- 16786814
OWN - NLM
STAT- MEDLINE
DCOM- 20060908
LR  - 20170214
IS  - 0706-7437 (Print)
IS  - 0706-7437 (Linking)
VI  - 51
IP  - 6
DP  - 2006 May
TI  - Genetic associations between delusional disorder and paranoid schizophrenia: A 
      novel etiologic approach.
PG  - 342-9
AB  - OBJECTIVES: Genetic associations between delusional disorder and paranoid 
      schizophrenia are not well understood, although involvement of biological factors 
      has been suspected. We investigated the incidence of human leukocyte antigen 
      (HLA) class I alleles in patients with delusional disorder and paranoid 
      schizophrenia, first, to explore a possible immunogenetic etiology of these 
      paranoid disorders and, second, to determine whether they share similar etiologic 
      mechanisms. METHOD: We employed a nested case-control study design. Psychiatric 
      reference data were available for 38,500 patients attending a hospital-based 
      psychiatric outpatient department between 1998 and 2005. We enrolled 100 patients 
      with delusional disorder and 50 patients with paranoid schizophrenia as the 
      subject cases, using DSM-IV criteria. We considered equivalent numbers of healthy 
      volunteers matched for age and ethnic background as control subjects. All 
      subjects came from an India-born Bengali population. We applied the polymerase 
      chain reaction-based molecular typing method to all patients and healthy 
      subjects. RESULTS: The HLA-A*03 gene is significantly associated with delusional 
      disorder as well as with paranoid schizophrenia. This HLA gene alone or in 
      linkage disequilibrium with other HLA genes or other closely linked non-HLA genes 
      may influence susceptibility to delusional disorder and paranoid schizophrenia. 
      CONCLUSIONS: The study reveals important associations between HLA genes and 
      paranoid disorders. Delusional disorder and paranoid schizophrenia may share 
      similar etiologic mechanisms. This preliminary observation may help our 
      understanding of the genetic basis of these paranoid disorders.
FAU - Debnath, Monojit
AU  - Debnath M
AD  - Department of Zoology, University of North Bengal, Siliguri, India.
FAU - Das, Sujit K
AU  - Das SK
FAU - Bera, Nirmal K
AU  - Bera NK
FAU - Nayak, Chitta R
AU  - Nayak CR
FAU - Chaudhuri, Tapas K
AU  - Chaudhuri TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Can J Psychiatry
JT  - Canadian journal of psychiatry. Revue canadienne de psychiatrie
JID - 7904187
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*03 antigen)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-A3 Antigen
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Immunogenetics
MH  - India
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Schizophrenia, Paranoid/diagnosis/*genetics/immunology/psychology
MH  - Statistics as Topic
EDAT- 2006/06/22 09:00
MHDA- 2006/09/09 09:00
CRDT- 2006/06/22 09:00
PHST- 2006/06/22 09:00 [pubmed]
PHST- 2006/09/09 09:00 [medline]
PHST- 2006/06/22 09:00 [entrez]
AID - 10.1177/070674370605100602 [doi]
PST - ppublish
SO  - Can J Psychiatry. 2006 May;51(6):342-9. doi: 10.1177/070674370605100602.