PMID- 16787272
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20190907
IS  - 1568-0266 (Print)
IS  - 1568-0266 (Linking)
VI  - 6
IP  - 10
DP  - 2006
TI  - Co-existence of GABA and Glu in the hippocampal granule cells: implications for 
      epilepsy.
PG  - 975-8
AB  - The granule cells of the Dentate Gyrus are one of the most exciting and 
      intriguing cells in the central nervous system. Besides containing and releasing 
      Glu, they have been shown to contain and release peptides (somatostatin, 
      neuropeptide Y, neurokinin B, cholecystokinin, dynorphin, enkephalin), Zn(++) 
      ion, and brain-derived neurotrophic factor (BDNF). The recent addition of GABA to 
      this list suggests that these cells can also function as inhibitory cells. 
      Indeed, evidence has been presented of co-localization of all markers of the 
      GABAergic phenotype in granule cells: GABA, the enzyme for its synthesis (Glu 
      decarboxylase) and the membrane and vesicular transporters of GABA. These markers 
      of the GABAergic phenotype are up-regulated after epileptic seizures. When this 
      occurs, monosynaptic GABA receptor-mediated transmission emerges in the mossy 
      fiber synapse thus restraining excitation and mediating antiepileptic and 
      neuroprotective actions.
FAU - Gutierrez, Rafael
AU  - Gutierrez R
AD  - Centro de Investigacion y Estudios Avanzados, Mexico City, Mexico. 
      grafael@fisio.cinvestav.mx
FAU - Heinemann, Uwe
AU  - Heinemann U
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Cytoplasmic Granules/*metabolism
MH  - Electric Stimulation
MH  - Epilepsy/*metabolism/physiopathology
MH  - Excitatory Postsynaptic Potentials
MH  - Glutamic Acid/*metabolism
MH  - Hippocampus/cytology/*metabolism/physiopathology
MH  - Humans
MH  - Magnetics
MH  - gamma-Aminobutyric Acid/*metabolism
RF  - 41
EDAT- 2006/06/22 09:00
MHDA- 2006/08/12 09:00
CRDT- 2006/06/22 09:00
PHST- 2006/06/22 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/06/22 09:00 [entrez]
AID - 10.2174/156802606777323692 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2006;6(10):975-8. doi: 10.2174/156802606777323692.