PMID- 16787875
OWN - NLM
STAT- MEDLINE
DCOM- 20061227
LR  - 20181113
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 83
IP  - 5
DP  - 2006 Jun
TI  - Adult T-cell leukemia in a liver transplant recipient that did not progress after 
      onset of graft rejection.
PG  - 429-32
AB  - A liver allograft recipient developed acute-type adult T-cell leukemia (ATL) 
      during tacrolimus treatment, 2 years after undergoing transplantation for 
      subacute fulminant hepatitis. Both donor and recipient were asymptomatic carriers 
      of human T-cell lymphotropic virus type I (HTLV-I), but the ATL cells originated 
      from the recipient. Tacrolimus treatment was discontinued, and combination 
      chemotherapy was administered. The patient achieved complete remission, but the 
      transplanted liver was acutely and chronically rejected. The patient did not 
      respond to rescue therapy with tacrolimus, prednisolone, and mycophenolate 
      mofetil and died of hepatic failure. Liver biopsies showed CD4+ ATL cell 
      infiltration at the onset of ATL but not at the terminal stage. Moreover, 
      Southern blotting revealed clonal integration of HTLV-I into the host genome of 
      lymphoma cells at onset but not at the terminal stage. ATL after liver 
      transplantation has not been previously described. The clinical course of the 
      posttransplantational ATL was atypical, because it did not progress after the 
      onset of rejection.
FAU - Suzuki, Shinsuke
AU  - Suzuki S
AD  - Department of Haematology, Kagoshima University Hospital, Kagoshima, Japan. 
      suzuki2@m.kufm.kagoshima-u.ac.jp
FAU - Uozumi, Kimiharu
AU  - Uozumi K
FAU - Maeda, Masahiko
AU  - Maeda M
FAU - Yamasuji, Yoshiko
AU  - Yamasuji Y
FAU - Hashimoto, Shin-ichi
AU  - Hashimoto S
FAU - Komorizono, Yasuji
AU  - Komorizono Y
FAU - Owatari, Satsuki
AU  - Owatari S
FAU - Tokunaga, Masahito
AU  - Tokunaga M
FAU - Haraguchi, Kouichi
AU  - Haraguchi K
FAU - Arima, Naomichi
AU  - Arima N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Fatal Outcome
MH  - Graft Rejection/drug therapy/etiology/virology
MH  - Hepatitis/*complications/pathology/therapy
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/drug therapy/*etiology
MH  - Liver Failure, Acute/*complications/pathology/therapy
MH  - *Liver Transplantation/adverse effects
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Transplantation, Homologous
EDAT- 2006/06/22 09:00
MHDA- 2006/12/28 09:00
CRDT- 2006/06/22 09:00
PHST- 2006/06/22 09:00 [pubmed]
PHST- 2006/12/28 09:00 [medline]
PHST- 2006/06/22 09:00 [entrez]
AID - 578V55841200N2P6 [pii]
AID - 10.1532/IJH97.05158 [doi]
PST - ppublish
SO  - Int J Hematol. 2006 Jun;83(5):429-32. doi: 10.1532/IJH97.05158.