PMID- 16787984
OWN - NLM
STAT- MEDLINE
DCOM- 20061012
LR  - 20220321
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 91
IP  - 9
DP  - 2006 Sep
TI  - Serum brain-derived neurotrophic factor concentrations in lean and overweight 
      children and adolescents.
PG  - 3548-52
AB  - CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be 
      important components of the leptin-signaling cascade involved in energy 
      homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive 
      adiposity. Little is known about the relationship between adiposity and BDNF, 
      particularly in children. OBJECTIVE: The objective of the study was to study the 
      association of serum BDNF with measures of adiposity in children. 
      DESIGN/SETTING/PATIENTS: BDNF was determined by a sandwich-type ELISA after an 
      overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for 
      extreme obesity. In 43, BDNF was also measured before, and again 1 h after, 
      consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: 
      Measures included associations between BDNF and measures of adiposity. RESULTS: 
      There were no significant univariate associations between log BDNF and adiposity 
      measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an 
      analysis of covariance accounting for age, sex, race, pubertal status, and 
      platelet count, BDNF was lower in overweight children (mean +/- sd, 39.8 +/- 24.8 
      vs. 47.0 +/- 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF 
      as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 
      0.02) were all negatively associated with BDNF once age, pubertal status, and 
      platelet count were included in the model. Ingestion of a meal did not 
      significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is 
      lower in extremely overweight children and adolescents than those of normal 
      weight. It remains to be determined whether obese individuals with low serum BDNF 
      for age and platelet count have mutations that alter BDNF function.
FAU - El-Gharbawy, Areeg H
AU  - El-Gharbawy AH
AD  - Unit on Growth and Obesity, National Institutes of Health, 10 Center Drive, 
      Hatfield Clinical Research Center, Room 1-3330, MSC 1103, Bethesda, Maryland 
      20892-1103, USA. jy15i@nih.gov
FAU - Adler-Wailes, Diane C
AU  - Adler-Wailes DC
FAU - Mirch, Margaret C
AU  - Mirch MC
FAU - Theim, Kelly R
AU  - Theim KR
FAU - Ranzenhofer, Lisa
AU  - Ranzenhofer L
FAU - Tanofsky-Kraff, Marian
AU  - Tanofsky-Kraff M
FAU - Yanovski, Jack A
AU  - Yanovski JA
LA  - eng
GR  - Z01 HD000641/ImNIH/Intramural NIH HHS/United States
GR  - Z01 HD000641-12/ImNIH/Intramural NIH HHS/United States
GR  - Z99 HD999999/ImNIH/Intramural NIH HHS/United States
GR  - HD-000641/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20060620
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Adult
MH  - Body Composition/*physiology
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Overweight/*physiology
MH  - Platelet Count
MH  - Plethysmography
PMC - PMC1863006
MID - NIHMS20417
EDAT- 2006/06/22 09:00
MHDA- 2006/10/13 09:00
PMCR- 2008/02/03
CRDT- 2006/06/22 09:00
PHST- 2006/06/22 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/06/22 09:00 [entrez]
PHST- 2008/02/03 00:00 [pmc-release]
AID - jc.2006-0658 [pii]
AID - 10.1210/jc.2006-0658 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2006 Sep;91(9):3548-52. doi: 10.1210/jc.2006-0658. Epub 
      2006 Jun 20.