PMID- 16790028
OWN - NLM
STAT- MEDLINE
DCOM- 20060921
LR  - 20131121
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 98
IP  - 4
DP  - 2006 Aug
TI  - Age-related effects of the neuromodulator D-serine on neurotransmission and 
      synaptic potentiation in the CA1 hippocampal area of the rat.
PG  - 1159-66
AB  - The effects of the co-agonist of the N-methyl-D-aspartate receptor (NMDAr) 
      D-serine on glutamatergic neurotransmission and synaptic potentiation were 
      studied in the CA1 hippocampal field of young (3-5 months old) and aged (25-27 
      months old) Sprague-Dawley rats using ex vivo extracellular electrophysiological 
      recording techniques. Exogenous d-serine depressed fast neurotransmission 
      mediated by the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate 
      subtype of glutamate receptors in young but not in aged rats by acting on 
      inhibitory glycinergic interneurons. In contrast, D-serine dose-dependently 
      enhanced NMDAr-mediated synaptic responses in both groups of animals, but with a 
      larger magnitude in aged rats, thus preventing the age-related decrease in NMDAr 
      activation. D-serine also increased the magnitude of long-term potentiation in 
      aged but not in young rats. Finally, D-serine levels were dramatically reduced in 
      hippocampal tissues of aged rats. Taken together, these results indicate a weaker 
      activation of the NMDAr glycine modulatory site by endogenous D-serine in aged 
      animals, which accounts for a reduced NMDAr contribution to synaptic plasticity 
      in ageing.
FAU - Junjaud, G
AU  - Junjaud G
AD  - Neurobiologie de la Croissance et de la Senescence, INSERM, Faculte de Medecine, 
      Universite Paris-Descartes, Paris, France.
FAU - Rouaud, E
AU  - Rouaud E
FAU - Turpin, F
AU  - Turpin F
FAU - Mothet, J-P
AU  - Mothet JP
FAU - Billard, J-M
AU  - Billard JM
LA  - eng
PT  - Journal Article
DEP - 20060621
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Kainic Acid)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 452VLY9402 (Serine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Electrophysiology
MH  - Glutamic Acid/physiology
MH  - Glycine/physiology
MH  - Hippocampus/*drug effects
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Nerve Net/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/drug effects
MH  - Receptors, Kainic Acid/drug effects
MH  - Receptors, N-Methyl-D-Aspartate/agonists/metabolism
MH  - Serine/*pharmacology
MH  - Synapses/*drug effects
MH  - Synaptic Transmission/*drug effects
EDAT- 2006/06/23 09:00
MHDA- 2006/09/22 09:00
CRDT- 2006/06/23 09:00
PHST- 2006/06/23 09:00 [pubmed]
PHST- 2006/09/22 09:00 [medline]
PHST- 2006/06/23 09:00 [entrez]
AID - JNC3944 [pii]
AID - 10.1111/j.1471-4159.2006.03944.x [doi]
PST - ppublish
SO  - J Neurochem. 2006 Aug;98(4):1159-66. doi: 10.1111/j.1471-4159.2006.03944.x. Epub 
      2006 Jun 21.