PMID- 16790273
OWN - NLM
STAT- MEDLINE
DCOM- 20061102
LR  - 20061115
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 27
IP  - 30
DP  - 2006 Oct
TI  - In vivo behavior of calcium phosphate scaffolds with four different pore sizes.
PG  - 5186-98
AB  - The goal of the present study was to assess the effect of macropore size on the 
      in vivo behavior of ceramic scaffolds. For that purpose, beta-tricalcium 
      phosphate (beta-TCP) cylinders with four different macropore sizes (150, 260, 
      510, and 1220 microm) were implanted into drill hole defects in cancellous bone 
      of sheep and their resorption behavior was followed for 6, 12 and 24 weeks. The 
      scaffolds were evaluated for biocompatibility, and new bone formation was 
      observed macroscopically, histologically and histomorphometrically. 
      Histomorphometrical measurements were performed for the whole defect area and for 
      the area subdivided into three concentric rings (outer, medial, and inner ring). 
      All implants were tolerated very well as evidenced by the low amount of 
      inflammatory cells and the absence of macroscopic signs of inflammation. 
      Resorption proceeded fast since less than 5% ceramic remained at 24-week 
      implantation. Hardly any effect of macropore size was observed on the in vivo 
      response. Samples with an intermediate macropore size (510 microm) were resorbed 
      significantly faster than samples with smaller macropore sizes (150 and 260 
      microm). However, this fast resorption was associated with a lower bone content 
      and a higher soft tissue content. At 12 and 24 weeks, the latter differences had 
      disappeared. Bone was more abundant in the outer ring than in the rest of the 
      blocks at 6 weeks, and in the outer and medial ring compared to the inner ring at 
      12 weeks.
FAU - von Doernberg, Marie-Cecile
AU  - von Doernberg MC
AD  - Musculoskeletal Research Unit (MSRU), Equine Hospital, University of Zurich, 
      Winterthurerstrasse 260, CH 8057 Zurich, Switzerland.
FAU - von Rechenberg, Brigitte
AU  - von Rechenberg B
FAU - Bohner, Marc
AU  - Bohner M
FAU - Grunenfelder, Sonja
AU  - Grunenfelder S
FAU - van Lenthe, G Harry
AU  - van Lenthe GH
FAU - Muller, Ralph
AU  - Muller R
FAU - Gasser, Beat
AU  - Gasser B
FAU - Mathys, Robert
AU  - Mathys R
FAU - Baroud, Gamal
AU  - Baroud G
FAU - Auer, Jorg
AU  - Auer J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060621
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
SB  - IM
MH  - Animals
MH  - *Bone Regeneration
MH  - Bone Substitutes/metabolism/*pharmacology
MH  - Bone and Bones/cytology/*drug effects/physiology
MH  - Calcium Phosphates/metabolism/*pharmacology
MH  - Female
MH  - Porosity
MH  - Sheep
EDAT- 2006/06/23 09:00
MHDA- 2006/11/03 09:00
CRDT- 2006/06/23 09:00
PHST- 2006/03/22 00:00 [received]
PHST- 2006/05/18 00:00 [accepted]
PHST- 2006/06/23 09:00 [pubmed]
PHST- 2006/11/03 09:00 [medline]
PHST- 2006/06/23 09:00 [entrez]
AID - S0142-9612(06)00490-X [pii]
AID - 10.1016/j.biomaterials.2006.05.051 [doi]
PST - ppublish
SO  - Biomaterials. 2006 Oct;27(30):5186-98. doi: 10.1016/j.biomaterials.2006.05.051. 
      Epub 2006 Jun 21.