PMID- 1679150
OWN - NLM
STAT- MEDLINE
DCOM- 19911002
LR  - 20220523
IS  - 0379-0355 (Print)
IS  - 0379-0355 (Linking)
VI  - 13
IP  - 6
DP  - 1991 Jul-Aug
TI  - Effects of antidepressants and antihistaminics on catalepsy induced by 
      intracerebroventricular administration of histamine in mice.
PG  - 397-403
AB  - The intracerebroventricular (icv) administration of histamine but not 
      N-telemethylhistamine and 1-methyl-4-imidazole acetic acid induced catalepsy in 
      mice. Histamine H1-receptor blockers such as cyproheptadine, mepyramine and 
      diphenhydramine reduced histamine-induced catalepsy. However, astemizole which is 
      known to be without central effects, did not reduce histamine-induced catalepsy. 
      The icv pretreatment with histamine H2-receptor blockers, such as metiamide and 
      cimetidine, also had no effect. Moreover, various antidepressants, both 
      imipramine- and atypical-type drugs antagonized histamine-induced catalepsy to 
      various degrees in this experiment. Thus, the induction of catalepsy by icv 
      administration of histamine was mediated through histamine H1-receptors, and 
      suggested that antidepressants reduced histamine-induced catalepsy via this 
      mechanism. Histamine-induced catalepsy is a possible new animal model of 
      depression which can also be used for evaluation of atypical antidepressants.
FAU - Onodera, K
AU  - Onodera K
AD  - Department of Pharmacology, Tohoku University School of Denistry, Sendai City, 
      Japan.
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Methods Find Exp Clin Pharmacol
JT  - Methods and findings in experimental and clinical pharmacology
JID - 7909595
RN  - 0 (Antidepressive Agents)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Receptors, Histamine H1)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage/*pharmacology
MH  - Catalepsy/*chemically induced
MH  - Histamine/administration & dosage
MH  - Histamine H1 Antagonists/administration & dosage/*pharmacology
MH  - Histamine H2 Antagonists/administration & dosage/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Receptors, Histamine H1/physiology
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
PST - ppublish
SO  - Methods Find Exp Clin Pharmacol. 1991 Jul-Aug;13(6):397-403.