PMID- 1679245
OWN - NLM
STAT- MEDLINE
DCOM- 19911003
LR  - 20220523
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 33
IP  - 3
DP  - 1991 May 17
TI  - Facilitation of baroreceptor reflex response by endogenous somatostatin in the 
      rat.
PG  - 239-50
AB  - We evaluated the potential participation of endogenous brain somatostatin-14 
      (SOM) in central cardiovascular regulation, using adult male Sprague-Dawley rats 
      anesthetized with pentobarbital sodium (40 mg/kg, i.p.). Intracerebroventricular 
      (i.c.v.) application of SOM (2 or 4 nmol) promoted a significant elevation in 
      baroreceptor reflex (BRR) response, induced by phenylephrine (5 micrograms kg, 
      i.v.). Blocking the endogenous SOM activity with its specific receptor 
      antagonist, cyclo-[7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)] (2 or 4 nmol, i.c.v.) 
      or antiserum against SOM (1:20, i.c.v.), on the other hand, appreciably 
      attenuated the same response. These modulatory effects on the BRR response were 
      essentially duplicated upon bilateral microinjections of SOM (320 pmol), SOM 
      antagonist (320 pmol) or anti-SOM (1:20) into the caudal portion of the nucleus 
      of tractus solitarius (NTS), the terminal site for baroreceptor afferents. These 
      results suggest that neurons that contain SOM may participate in cardiovascular 
      control by tonically facilitating the BRR, possibly by exerting an influence on 
      the neurons at the NTS.
FAU - Lin, S S
AU  - Lin SS
AD  - Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan, 
      Republic of China.
FAU - Chan, J Y
AU  - Chan JY
FAU - Chan, S H
AU  - Chan SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Receptors, Neurotransmitter)
RN  - 0 (Receptors, Somatostatin)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 51110-01-1 (Somatostatin)
RN  - 84211-54-1 (cyclo(7-aminoheptanoylphenylalanyl-tryptophyl-lysyl-benzylthreonyl))
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects/physiology
MH  - Hypertension/chemically induced/drug therapy
MH  - Male
MH  - Medulla Oblongata/drug effects/physiology
MH  - Microinjections
MH  - Neurons, Afferent/drug effects/physiology
MH  - Phenylephrine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Neurotransmitter/antagonists & inhibitors
MH  - Receptors, Somatostatin
MH  - Somatostatin/analogs & derivatives/antagonists & 
      inhibitors/pharmacokinetics/*pharmacology
MH  - Time Factors
EDAT- 1991/05/17 00:00
MHDA- 1991/05/17 00:01
CRDT- 1991/05/17 00:00
PHST- 1991/05/17 00:00 [pubmed]
PHST- 1991/05/17 00:01 [medline]
PHST- 1991/05/17 00:00 [entrez]
AID - 0167-0115(91)90227-8 [pii]
AID - 10.1016/0167-0115(91)90227-8 [doi]
PST - ppublish
SO  - Regul Pept. 1991 May 17;33(3):239-50. doi: 10.1016/0167-0115(91)90227-8.