PMID- 16792590
OWN - NLM
STAT- MEDLINE
DCOM- 20061128
LR  - 20151119
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 61
IP  - 7
DP  - 2006 Jul
TI  - HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced 
      occupational asthma?
PG  - 891-4
AB  - BACKGROUND: There has been no study for evaluating the associations of human 
      leukocyte antigen (HLA) class I and II alleles with toluene diisocyanate 
      (TDI)-induced asthma in an Asian population. OBJECTIVE: The aim of this study was 
      to investigate a susceptible or protective marker of HLA class I and II alleles 
      in TDI-induced asthma. METHODS: Fifty-five patients with TDI-induced asthma 
      patients (group I) showing positive responses on TDI bronchoprovocation test, 47 
      asymptomatic exposed subjects (group II) and 95 unexposed healthy nonatopic 
      controls (group III) were enrolled in our study. HLA class I and II genotyping 
      was done by the direct DNA sequencing method. RESULTS: The allelic frequency of 
      C*09 (15.5%) was significantly higher in group I than in group III (6.8%, P = 
      0.019), but this statistical significance disappeared after correction was made 
      for multiple comparisons. On two-locus and three-locus haplotype analysis, the 
      allelic frequency of HLA DRB1*15-DPB1*05 in group I (10.6%) was significantly 
      higher than that of group II (0%, P = 0.001) and group III (2.5%, P = 0.003). The 
      allelic frequencies of HLA A*02-DRB1*15, A*02-DQB1*06, B*62-C*09 and 
      A*02-DRB1*15-DQB1*06 were significantly higher in group I (8.5%, 10.3%, 8.2% and 
      6.8%, respectively) than those allelic frequencies of group III (1.3%, P = 0.002; 
      1.6%, P = 0.001; 0.6%, P < 0.0001; 0%, P < 0.0001, respectively). The allelic 
      frequencies of HLA DQB1*06-DPB1*05 and DRB1*15-DQB1*06-DPB1*05 were significantly 
      higher in group I (16.0% and 10.5%) than those in group II (2.5%, P = 0.001; 0%, 
      P = 0.001), while the frequencies of DRB1*09-DPB1*05 and 
      DRB1*09-DQB1*0303-DPB1*05 were significantly lower in group I (0% and 0%) than 
      those of group II (7.4%, P = 0.004; 7.5%, P = 0.004). These differences remained 
      statistically significant even after the correction for multiple comparisons. 
      CONCLUSIONS: The HLA haplotype DRB1*15-DPB1*05 can be a susceptibility gene 
      marker for the development of TDI-induced asthma among the exposed workers in the 
      Korean population.
FAU - Kim, S-H
AU  - Kim SH
AD  - Department of Allergy and Rheumatology, Ajou University School of Medicine, 
      Suwon, Korea.
FAU - Oh, H-B
AU  - Oh HB
FAU - Lee, K-W
AU  - Lee KW
FAU - Shin, E-S
AU  - Shin ES
FAU - Kim, C-W
AU  - Kim CW
FAU - Hong, C-S
AU  - Hong CS
FAU - Nahm, D-H
AU  - Nahm DH
FAU - Park, H-S
AU  - Park HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Biomarkers)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
SB  - IM
MH  - Adult
MH  - Asthma/chemically induced/*genetics
MH  - Biomarkers
MH  - Bronchial Provocation Tests
MH  - Bronchoconstrictor Agents/pharmacology
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Korea
MH  - Male
MH  - Methacholine Chloride/pharmacology
MH  - Middle Aged
MH  - Occupational Diseases/chemically induced/*genetics
MH  - Occupational Exposure/adverse effects
MH  - Skin Tests
MH  - Toluene 2,4-Diisocyanate/*toxicity
EDAT- 2006/06/24 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/06/24 09:00
PHST- 2006/06/24 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/06/24 09:00 [entrez]
AID - ALL1023 [pii]
AID - 10.1111/j.1398-9995.2006.01023.x [doi]
PST - ppublish
SO  - Allergy. 2006 Jul;61(7):891-4. doi: 10.1111/j.1398-9995.2006.01023.x.