PMID- 16793032
OWN - NLM
STAT- MEDLINE
DCOM- 20060915
LR  - 20151119
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 370
IP  - 1-2
DP  - 2006 Aug
TI  - Pro-inflammatory states and IGF-I level in ischemic heart disease with low or 
      high serum iron.
PG  - 50-6
AB  - BACKGROUND: Serum iron overload or iron deficiency appears to be associated with 
      atherosclerosis and ischemic myocardial damage. Roles of low or high serum iron 
      in patients with ischemic heart diseases are still controversial. METHODS: Serum 
      samples for biochemical and immunologic analyses were collected from the 73 
      normal subjects and the 90 patients with ischemic heart disease (IHD), the latter 
      of which were selected from 142 patients and classified by low, normal and high 
      serum iron. RESULTS: Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 
      (IL-6), high sensitive C-Reactive protein (hsCRP), and interleukin-10 (IL-10) 
      were increased and insulin-like growth factor (IGF)-I was decreased in IHD 
      patients with low serum iron, whereas these parameters were not changed in IHD 
      patients with normal or high serum iron, compared with normal subjects. Total 
      bilirubin was increased in IHD patients with high serum iron but was not changed 
      in IHD patients with low or normal serum iron, compared with normal subjects. 
      CONCLUSION: The IHD patients with low serum iron were associated with a 
      pro-inflammatory state, such as increased TNF-alpha, IL-6, and hsCRP; increased 
      anti-inflammatory activities, such as increased IL-10; decreased cardiac 
      protective factor, such as decreased IGF-I. These findings may imply that IHD 
      patients with low serum irons were associated with less cardiac protection and 
      more pro-inflammatory states than normal subjects or IHD patients with either 
      normal or high serum iron.
FAU - Lee, Shin-Da
AU  - Lee SD
AD  - School of Physical Therapy, Chung-Shan Medical University, Taichung, Taiwan.
FAU - Huang, Chih-Yang
AU  - Huang CY
FAU - Shu, Wen-Tong
AU  - Shu WT
FAU - Chen, Ter-Hsin
AU  - Chen TH
FAU - Lin, James A
AU  - Lin JA
FAU - Hsu, Hsi-Hsien
AU  - Hsu HH
FAU - Lin, Chung-Sheng
AU  - Lin CS
FAU - Liu, Chung-Jung
AU  - Liu CJ
FAU - Kuo, Wei-Wen
AU  - Kuo WW
FAU - Chen, Li-Mien
AU  - Chen LM
LA  - eng
PT  - Journal Article
DEP - 20060621
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Aged
MH  - Antioxidants/metabolism
MH  - Biomarkers
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - Growth Hormone/blood
MH  - Humans
MH  - Inflammation/blood/pathology
MH  - Inflammation Mediators/blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Interleukin-6/metabolism
MH  - Iron/*blood
MH  - Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood/*pathology
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2006/06/24 09:00
MHDA- 2006/09/16 09:00
CRDT- 2006/06/24 09:00
PHST- 2005/11/01 00:00 [received]
PHST- 2006/01/15 00:00 [revised]
PHST- 2006/01/16 00:00 [accepted]
PHST- 2006/06/24 09:00 [pubmed]
PHST- 2006/09/16 09:00 [medline]
PHST- 2006/06/24 09:00 [entrez]
AID - S0009-8981(06)00069-6 [pii]
AID - 10.1016/j.cca.2006.01.012 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2006 Aug;370(1-2):50-6. doi: 10.1016/j.cca.2006.01.012. Epub 2006 
      Jun 21.