PMID- 1679367
OWN - NLM
STAT- MEDLINE
DCOM- 19911004
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 547
IP  - 2
DP  - 1991 May 3
TI  - Retinogeniculate transmission by NMDA and non-NMDA receptors in the cat.
PG  - 229-38
AB  - The contributions of N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino 
      acid (EAA) receptors to retinogeniculate transmission were investigated in the 
      cat. The EAA antagonists 2-amino-5-phosphonovaleric acid (APV) and kynurenic acid 
      (KYN) were used to block the NMDA receptors and all EAA receptors, respectively. 
      Antagonistic effects on the visual response were assessed with single On/Off 
      stimuli of 2 s duration or repetitive flicker stimulation (5 Hz) with a light 
      spot projected onto the receptive field center. With APV, the NMDA response could 
      be almost completely abolished but the visual response to repetitive stimulation 
      was reduced on average by only 34%. Initial (transient) components of the single 
      flash response were attenuated on average by 23%, the residual (sustained) 
      component by 48%. With KYN the responses to NMDA, quisqualate (QUIS) and 
      glutamate (GLU) were abolished or strongly reduced as was the visual response to 
      flicker (mean 58%) and single flash stimulation (mean transient 73%, sustained 
      90%). Prolonged iontophoretic applications of the agonists GLU, QUIS and NMDA 
      revealed receptor desensitization or competitive interactions with the naturally 
      released transmitter in a dose-dependent manner. When the responses to any of the 
      3 agonists declined during continuous application, superimposed visual responses 
      were clearly reduced in amplitude. Visual response amplitudes were also reduced 
      when superimposed on steady state QUIS responses but unchanged in amplitude when 
      superimposed on steady state NMDA responses. In conclusion, non-NMDA as well as 
      NMDA receptors seem to participate in cat retinogeniculate transmission. Non-NMDA 
      receptors appear to be most important for the initial component but can also 
      maintain the visual response, while the NMDA receptors seem to be more effective 
      during the later component of the response.
FAU - Funke, K
AU  - Funke K
AD  - Abteilung fur Neurophysiologie, Ruhr-Universitat Bochum, F.R.G.
FAU - Eysel, U T
AU  - Eysel UT
FAU - FitzGibbon, T
AU  - FitzGibbon T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Glutamates)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 8OC22C1B99 (Quisqualic Acid)
RN  - H030S2S85J (Kynurenic Acid)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - Animals
MH  - Cats
MH  - Geniculate Bodies/*physiology
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Iontophoresis
MH  - Kynurenic Acid/pharmacology
MH  - N-Methylaspartate/pharmacology
MH  - Photic Stimulation
MH  - Quisqualic Acid/pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/*drug effects
MH  - Retina/*physiology
MH  - Synaptic Transmission/*physiology
EDAT- 1991/05/03 00:00
MHDA- 1991/05/03 00:01
CRDT- 1991/05/03 00:00
PHST- 1991/05/03 00:00 [pubmed]
PHST- 1991/05/03 00:01 [medline]
PHST- 1991/05/03 00:00 [entrez]
AID - 0006-8993(91)90966-Y [pii]
AID - 10.1016/0006-8993(91)90966-y [doi]
PST - ppublish
SO  - Brain Res. 1991 May 3;547(2):229-38. doi: 10.1016/0006-8993(91)90966-y.