PMID- 16793900
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20181113
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 575
IP  - Pt 2
DP  - 2006 Sep 1
TI  - Membrane potential-regulated Ca2+ signalling in development and maturation of 
      mammalian cerebellar granule cells.
PG  - 389-95
AB  - In many developing neuronal cell types, the resting membrane potential is 
      relatively depolarized, then gradually hyperpolarizes during the early postnatal 
      period. The regulatory roles of membrane potential changes in neuronal 
      development and maturation have been extensively studied in developing cerebellar 
      granule cells, using primary culture under depolarizing and non-depolarizing 
      conditions in combination with in vivo analysis. Depolarization enhances calcium 
      entry via voltage-sensitive Ca2+ channels (VSCCs) and activates 
      Ca2+-calmodulin-dependent protein kinase (CaMK) and calcineurin phophatase (CaN). 
      The activation of CaN induces many genes encoding extracellular and intracellular 
      signalling molecules implicated in granule cell development. The inactivation of 
      CaN in turn up-regulates many other genes characteristic of mature granule cells, 
      including NR2C NMDA receptor and GABAAalpha1 and alpha6 receptors. The induction 
      of NR2C also requires CaMK-up-regulated brain-derived neurotrophic factor (BDNF), 
      indicating a convergence of signalling mechanism of the CaMK and CaN cascades. 
      The inactivation of CaN maintains the phosphorylated and sumoylated form of a 
      transcriptional myocyte enhances factor 2A (MEF2A) regulator. This form of MEF2A 
      acts as a transcriptional repressor and is essential for the dendritic 
      morphogenesis of differentiated granule cells. Collectively, the membrane 
      potential change and the resulting Ca2+ signalling play a pivotal role in 
      development and maturation of neuronal cells.
FAU - Nakanishi, Shigetada
AU  - Nakanishi S
AD  - Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, Japan. 
      snakanis@obi.or.jp
FAU - Okazawa, Makoto
AU  - Okazawa M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060622
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Animals
MH  - Calcium Signaling/*physiology
MH  - Cell Differentiation/physiology
MH  - Cerebellum/*cytology/growth & development/physiology
MH  - Gene Expression Regulation/genetics/physiology
MH  - Humans
MH  - Mammals/physiology
MH  - Membrane Potentials/*physiology
MH  - Neurons/*cytology/*physiology
MH  - Synapses/genetics/physiology
PMC - PMC1819456
EDAT- 2006/06/24 09:00
MHDA- 2006/10/27 09:00
PMCR- 2007/09/01
CRDT- 2006/06/24 09:00
PHST- 2006/06/24 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/06/24 09:00 [entrez]
PHST- 2007/09/01 00:00 [pmc-release]
AID - jphysiol.2006.113340 [pii]
AID - 10.1113/jphysiol.2006.113340 [doi]
PST - ppublish
SO  - J Physiol. 2006 Sep 1;575(Pt 2):389-95. doi: 10.1113/jphysiol.2006.113340. Epub 
      2006 Jun 22.