PMID- 16796384
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20190516
IS  - 1550-7416 (Electronic)
IS  - 1550-7416 (Linking)
VI  - 8
IP  - 2
DP  - 2006 May 12
TI  - Causes and consequences of methamphetamine and MDMA toxicity.
PG  - E337-47
AB  - Methamphetamine (METH) and its derivative 3,4-methylenedioxymethamphetamine 
      (MDMA; ecstasy) are 2 substituted amphetamines with very high abuse liability in 
      the United States. These amphetamine-like stimulants have been associated with 
      loss of multiple markers for dopaminergic and serotonergic terminals in the 
      brain. Among other causes, oxidative stress, excitotoxicity and mitochondrial 
      dysfunction appear to play a major role in the neurotoxicity produced by the 
      substituted amphetamines. The present review will focus on these events and how 
      they interact and converge to produce the monoaminergic depletions that are 
      typically observed after METH or MDMA administration. In addition, more recently 
      identified consequences of METH or MDMA-induced oxidative stress, excitotoxicity, 
      and mitochondrial dysfunction are described in relation to the classical markers 
      of METH-induced damage to dopamine terminals.
FAU - Quinton, Maria S
AU  - Quinton MS
AD  - Department of Pharmacology and Experimental Therapeutics, Boston University 
      School of Medicine, Room L -613, 715 Albany Street, Boston, MA 02118, USA.
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060512
PL  - United States
TA  - AAPS J
JT  - The AAPS journal
JID - 101223209
RN  - 0 (Neurotoxins)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Blood-Brain Barrier
MH  - Dopamine/physiology
MH  - Humans
MH  - Methamphetamine/*toxicity
MH  - Mitochondria/drug effects/pathology/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurotoxins/*toxicity
MH  - Oxidative Stress/drug effects
MH  - Substance-Related Disorders/*epidemiology
MH  - United States/epidemiology
PMC - PMC3231568
EDAT- 2006/06/27 09:00
MHDA- 2006/08/12 09:00
PMCR- 2007/05/12
CRDT- 2006/06/27 09:00
PHST- 2006/06/27 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/06/27 09:00 [entrez]
PHST- 2007/05/12 00:00 [pmc-release]
AID - BF02854904 [pii]
AID - 10.1007/BF02854904 [doi]
PST - epublish
SO  - AAPS J. 2006 May 12;8(2):E337-47. doi: 10.1007/BF02854904.