PMID- 16796855
OWN - NLM
STAT- MEDLINE
DCOM- 20080414
LR  - 20060626
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 86
IP  - 17
DP  - 2006 May 9
TI  - [The clinical value of B-type natriuretic peptide in the diagnosis of left heart 
      failure].
PG  - 1165-9
AB  - OBJECTIVE: To evaluate the diagnostic value of B-type natriuretic peptide (BNP) 
      in the diagnosis of left heart failure (HF) or left ventricular systolic 
      dysfunction. METHODS: Samples of peripheral venous blood were collected from 243 
      consecutive patients with left HF and 111 normal controls (control group, CG) to 
      measured BNP level with fluorescence immunoassay method. The patients with left 
      HF were divided into 2 groups: those with the left ventricular ejection fraction 
      (LVEF) </= 40% (n = 111) and those with the LVEF > 40% (n = 132) according to the 
      level of LVEF; or into 2 groups: compensated heart failure group (CHF group, at 
      NYHA grade I - II, n = 110) and decompensated heart failure group (DHF group, at 
      NYHA grade III - IV, n = 133) according to the New York Heart Association (NYHA) 
      functional class. RESULTS: The plasma level of BNP of the left HF group was 292.0 
      ng/L, significantly higher than that of the CG (17.9 ng/L, P < 0.001). The plasma 
      BNP of the group with the LVEF </= 40% was 471.0 ng/L, significantly than that of 
      the group with the LVEF > 40% (138.5 ng/L, P < 0.001). The plasma BNP of the DHF 
      group was 579.0 ng/L, significantly higher than that of the of the CHF group 
      (84.8 ng/L, P < 0.001). The values of area under the curve (AUC) of receiver 
      operator characteristic curve were all > 0.9 in the diagnosis of presence of HF 
      (AUC = 0.927), HF with the LVEF </= 40% (AUC = 0.989), and DHF (AUC = 0.991), and 
      in the differential diagnosis between CHF and DHF (AUC = 0.941). When 90.0 pg/ml 
      was used as cutoff value to diagnose left HF, heart failure with the LVEF </= 
      40%, and decompensation, the positive predictive value (PPV) were 98.9%, 98.1%, 
      and 98.5% respectively, and the negative predictive value (NPV) were 64.5%, 
      94.0%, and 96.5% respectively. When 50.0 pg/ml was used as the cutoff value to 
      diagnose HF with the LVEF > 40% and compensated heart failure, the PPV were 88.0% 
      and 84.7%, the NPV were 72.6% and 72.1% respectively. CONCLUSION: The diagnostic 
      value of BNP is high for the diagnosis of more severely impaired LVEF and 
      decompensated heart failure with 90.0 pg/ml as the cutoff value, and if 50.0 
      pg/ml is used as the cutoff value, the value is also good for the diagnosis of HF 
      with the LVEF > 40% and compensated heart failure.
FAU - Zhao, Xue-Yan
AU  - Zhao XY
AD  - Department of Cardiology, Cardiovascular Institute and Fuwai Hospital, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, 
      China.
FAU - Yang, Yue-Jin
AU  - Yang YJ
FAU - Zhang, Jian
AU  - Zhang J
FAU - Dang, Ai-Min
AU  - Dang AM
FAU - Ni, Xin-Hai
AU  - Ni XH
FAU - Huang, Jie
AU  - Huang J
FAU - Kang, Sheng
AU  - Kang S
FAU - Ma, Wei-Hua
AU  - Ma WH
FAU - Zhao, Dong-Yun
AU  - Zhao DY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fluoroimmunoassay
MH  - Heart Failure/*diagnosis/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*analysis
MH  - Predictive Value of Tests
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnosis/metabolism
EDAT- 2006/06/27 09:00
MHDA- 2008/04/15 09:00
CRDT- 2006/06/27 09:00
PHST- 2006/06/27 09:00 [pubmed]
PHST- 2008/04/15 09:00 [medline]
PHST- 2006/06/27 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2006 May 9;86(17):1165-9.