PMID- 16797081
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20090928
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 96
IP  - 1-2
DP  - 2006 Nov
TI  - Association study of BDNF and CNTF polymorphism to depression in non-demented 
      subjects of the "VITA" study.
PG  - 111-6
AB  - BACKGROUND: Neurotrophic factors are known to play an important role in the 
      survival and differentiation of many types of neurons during development. Both 
      brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) 
      may act cooperatively in modulating the development and functioning of synapses. 
      Both these neurotrophic factors were intensely investigated with regard to 
      depression without conclusive results. METHODS: We have investigated the possible 
      use of both CNTF null-mutation and BDNF polymorphism C270T as biomarkers for 
      depression in the Vienna Transdanube Aging (VITA) study. The VITA is a 
      prospective community-based cohort study of all 75 years old inhabitants of a 
      geographical region of Vienna. RESULTS: We found no association between CNTF 
      null-mutation and BDNF C270T polymorphism to any depressive symptoms after 
      exclusion of demented subjects. CONCLUSION: These results call in question the 
      hypothesis that either BDNF or CNTF can be used as molecular markers for 
      depression or late onset depression in the elderly.
FAU - Grunblatt, E
AU  - Grunblatt E
AD  - Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, 
      Austria. edna.gruenblatt@mail.uni-wuerzburg.de
FAU - Hupp, E
AU  - Hupp E
FAU - Bambula, M
AU  - Bambula M
FAU - Zehetmayer, S
AU  - Zehetmayer S
FAU - Jungwirth, S
AU  - Jungwirth S
FAU - Tragl, K H
AU  - Tragl KH
FAU - Fischer, P
AU  - Fischer P
FAU - Riederer, P
AU  - Riederer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060622
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Alzheimer Disease/genetics
MH  - Austria
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Ciliary Neurotrophic Factor/*genetics
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Depressive Disorder/*genetics
MH  - Depressive Disorder, Major/genetics
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Prospective Studies
EDAT- 2006/06/27 09:00
MHDA- 2007/02/13 09:00
CRDT- 2006/06/27 09:00
PHST- 2006/01/31 00:00 [received]
PHST- 2006/05/12 00:00 [revised]
PHST- 2006/05/12 00:00 [accepted]
PHST- 2006/06/27 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/06/27 09:00 [entrez]
AID - S0165-0327(06)00228-X [pii]
AID - 10.1016/j.jad.2006.05.008 [doi]
PST - ppublish
SO  - J Affect Disord. 2006 Nov;96(1-2):111-6. doi: 10.1016/j.jad.2006.05.008. Epub 
      2006 Jun 22.