PMID- 16797748
OWN - NLM
STAT- MEDLINE
DCOM- 20070404
LR  - 20131121
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 115
IP  - 2
DP  - 2007 Feb 7
TI  - Coronary flow, VO2 peak and anaerobic threshold in patients with dilated 
      cardiomyopathy.
PG  - 251-6
AB  - BACKGROUND: Coronary flow is influenced by several determinants and may change 
      according to external stimuli. In patients with dilated cardiomyopathy (DC), 
      adaptive mechanisms could induce alterations in coronary flow, possibly related 
      to oxygen consumption. METHODS: In 67 consecutive patients with DC (mean age 
      52.06+/-13.84, 52 male gender, left ventricle ejection fraction (LVEF) 
      29.49%+/-8.68) and normal coronary angiography findings, coronary flow in left 
      anterior descending (LAD), right coronary artery (RC) and left circumflex (LCx) 
      was reported as TIMI frame count (TFC). All patients underwent a cardiopulmonary 
      test with VO2 peak and anaerobic threshold (AT) measurement, New York Heart 
      Association (NYHA) class stratification, two-dimensional echocardiographic 
      evaluation including LVEF and left ventricle end-diastolic diameter (LVEDD) 
      assessment. All patients were receiving optimal medical treatment. RESULTS: In a 
      multivariate analysis, a statistically significant correlation was found between 
      VO2 peak and TFC (B 7.61, p<0.001, R2 0.61 for LAD; B 3.42, p<0.001, R2 0.33 for 
      RC); an inverse correlation was found between AT and TFC (B -9.77, p<0.001, R2 
      0.61 for LAD; B -4.26, p<0.001, R2 0.33 for RC). CONCLUSIONS: Coronary flow is 
      related to VO2 peak and AT in patients with DC, suggesting a "compensatory" 
      mechanism.
FAU - Brunetti, N D
AU  - Brunetti ND
FAU - Lepera, M E
AU  - Lepera ME
FAU - Greco, A
AU  - Greco A
FAU - Quagliara, D
AU  - Quagliara D
FAU - Zanna, D
AU  - Zanna D
FAU - Quistelli, G
AU  - Quistelli G
FAU - Di Biase, M
AU  - Di Biase M
FAU - Rizzon, P
AU  - Rizzon P
LA  - eng
PT  - Letter
DEP - 20060623
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Anaerobic Threshold
MH  - Cardiomyopathy, Dilated/*blood/*physiopathology
MH  - *Coronary Circulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen/*metabolism
EDAT- 2006/06/27 09:00
MHDA- 2007/04/05 09:00
CRDT- 2006/06/27 09:00
PHST- 2005/12/06 00:00 [received]
PHST- 2006/01/27 00:00 [accepted]
PHST- 2006/06/27 09:00 [pubmed]
PHST- 2007/04/05 09:00 [medline]
PHST- 2006/06/27 09:00 [entrez]
AID - S0167-5273(06)00312-3 [pii]
AID - 10.1016/j.ijcard.2006.01.041 [doi]
PST - ppublish
SO  - Int J Cardiol. 2007 Feb 7;115(2):251-6. doi: 10.1016/j.ijcard.2006.01.041. Epub 
      2006 Jun 23.