PMID- 16800378
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20220317
IS  - 0379-4172 (Print)
IS  - 0379-4172 (Linking)
VI  - 33
IP  - 6
DP  - 2006 Jun
TI  - Somatic cell and sperm cell cytogenetics in a patient with t(14; 21).
PG  - 488-94
AB  - Approximately 15%-20% of clinically recognizable pregnancies end in spontaneous 
      abortion. About half of the spontaneous abortions in the early stage of the 
      pregnancy are due to chromosomal abnormalities. Using GTG chromosome banding and 
      dual-color fluorescence in situ hybridization (FISH) techniques, we determined 
      the cytogenetic aberration in the husband of a couple with spontaneous recurrent 
      abortions. Karyotype analysis showed 46, XX in the wife and 45, XY, -14, -21, 
      +t(14; 21) in the husband. We studied the mechanism of formation of the abnormal 
      chromosome with Robertsonian translocation between chromosomes 14 and 21 by FISH 
      and flow cytometric sorting in the sperm cells. The result showed that 71% of the 
      gametes were balanced and the remaining 29% were not. As a result, the couple was 
      given genetic counseling.
FAU - Tang, Yan-Ping
AU  - Tang YP
AD  - Center for Reproductive Medicine, Tongji Medical College, Huazhong University of 
      Science and Technology, Wuhan, China.
FAU - Liu, Xiu-Sheng
AU  - Liu XS
FAU - Liu, Yuan
AU  - Liu Y
FAU - Yang, Zhen-Rong
AU  - Yang ZR
FAU - Chen, Yan
AU  - Chen Y
FAU - Xiong, Cheng-Liang
AU  - Xiong CL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yi Chuan Xue Bao
JT  - Yi chuan xue bao = Acta genetica Sinica
JID - 7900784
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 21
MH  - Chromosomes, Human, X
MH  - Chromosomes, Human, Y
MH  - Cytogenetic Analysis
MH  - Female
MH  - Flow Cytometry
MH  - Genetic Counseling
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Spermatozoa/*pathology
MH  - *Translocation, Genetic
EDAT- 2006/06/28 09:00
MHDA- 2009/05/30 09:00
CRDT- 2006/06/28 09:00
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
AID - S0379-4172(06)60076-0 [pii]
AID - 10.1016/S0379-4172(06)60076-0 [doi]
PST - ppublish
SO  - Yi Chuan Xue Bao. 2006 Jun;33(6):488-94. doi: 10.1016/S0379-4172(06)60076-0.