PMID- 16800825
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20191210
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 11
IP  - 2
DP  - 2006 Jun
TI  - Different effects of chronic phencyclidine on brain-derived neurotrophic factor 
      in neonatal and adult rat brains.
PG  - 126-30
AB  - The N-methyl-D-aspartate (NMDA) receptor and brain-derived neurotrophic factor 
      (BDNF) are both known to play major roles in the normal development of the brain. 
      We have hypothesized that the chronic blockade of NMDA with phencyclidine (PCP) 
      may have a different effect on BDNF synthesis at different stages of development. 
      In an acute experiment, rat pups and adult rats were injected with PCP (2.5, 5 or 
      10 mg/kg) at postnatal day (PD) 15 or 49, respectively. In a chronic experiment, 
      rat pups were injected daily from PD 5 to PD 14 with PCP (2.5, 5 or 10 mg/kg), 
      while adult rats were injected daily with the same dose from PD 39 to PD 48. BDNF 
      levels in the hippocampus, striatum and frontal cortex were determined by ELISA 
      assay 24 hours after the last injection. Chronic PCP treatment of neonatal rats 
      induced a dose-dependent decrease in BDNF in the hippocampus but not in the 
      frontal cortex and striatum. Single injection of PCP to rat pups showed a slight 
      reduction of BDNF in the hippocampus but only at higher doses. In contrast to 
      neonatal brain, neither acute nor chronic injection of PCP influenced BDNF in 
      adult brain. These findings suggest that chronic blockade of NMDA receptor in the 
      early neonatal period has an inhibitory effect on BDNF synthesis in the 
      hippocampus and may impair normal neurodevelopment in rat pups.
FAU - Semba, Jun'ichi
AU  - Semba J
AD  - Division of Health Sciences, University of the Air, Japan. sem-baj@u-air.ac.jp
FAU - Wakuta, Maki
AU  - Wakuta M
FAU - Suhara, Tetsuya
AU  - Suhara T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*drug effects/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/administration & dosage/*pharmacology
MH  - Phencyclidine/administration & dosage/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2006/06/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/06/28 09:00
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
AID - ADB023 [pii]
AID - 10.1111/j.1369-1600.2006.00023.x [doi]
PST - ppublish
SO  - Addict Biol. 2006 Jun;11(2):126-30. doi: 10.1111/j.1369-1600.2006.00023.x.