PMID- 16800826
OWN - NLM
STAT- MEDLINE
DCOM- 20061130
LR  - 20131121
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 11
IP  - 2
DP  - 2006 Jun
TI  - Long-term voluntary consumption of MDMA and THC in rats is modified by individual 
      and situational factors.
PG  - 131-44
AB  - Factors influencing long-term voluntary intake of 
      3,4-methylenedioxymethamphetamine (MDMA; ecstasy) and Delta9-tetrahydrocannabinol 
      (THC; cannabis) were studied in a rat model. Sixty-four male Wistar rats were 
      given free choice for 49 weeks between (1) water and MDMA solution, (2) water and 
      THC solution or (3) water, MDMA solution and THC solution. After the first 
      experiences with the drugs, animals of both monodrug and polydrug group developed 
      an individually stable pattern of MDMA consumption, whereas the individual 
      predictability of THC consumption remained poor. While THC consumption was 
      maintained for the whole experimental period, MDMA consumption decreased with 
      time and was nearly ceased after 3-7 months. Intake of both drugs was adapted to 
      social changes, with THC consumption being more sensitive to social changes than 
      MDMA consumption. In the re-test after 4 months of abstinence, all animals ceased 
      drug consumption when the drug solutions were adulterated with bitter tasting 
      quinine. The results show that the rats had maintained a flexible mode of drug 
      consumption and had not become addicted. Response to novelty of the rats in test 
      trials before the start of drug supply correlated with later MDMA intake. In 
      conclusion, although very low amounts of MDMA and/or THC were consumed, the 
      findings that drug-experienced animals responded differentially to a stressor and 
      that housing conditions influenced drug intake suggests that MDMA and THC can 
      induce psychopharmacological effects in our long-term voluntary consumption 
      paradigm.
FAU - Reinhard, Carola
AU  - Reinhard C
AD  - Section of Addiction Reseasrch, Department of Psychiatry, University Hospital, 
      Tuebingen, Germany. ukt-reinhard@medimod.com
FAU - Wolffgramm, Jochen
AU  - Wolffgramm J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Hallucinogens)
RN  - 7J8897W37S (Dronabinol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Choice Behavior/*drug effects
MH  - Disease Models, Animal
MH  - Dronabinol/administration & dosage/*pharmacology
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Social Behavior
MH  - Substance-Related Disorders/*epidemiology
MH  - Time Factors
EDAT- 2006/06/28 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/06/28 09:00
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
AID - ADB022 [pii]
AID - 10.1111/j.1369-1600.2006.00022.x [doi]
PST - ppublish
SO  - Addict Biol. 2006 Jun;11(2):131-44. doi: 10.1111/j.1369-1600.2006.00022.x.