PMID- 16801033
OWN - NLM
STAT- MEDLINE
DCOM- 20060802
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 105
IP  - 6
DP  - 2006 Jun
TI  - Six-month nocturnal nasal positive pressure ventilation improves respiratory 
      muscle capacity and exercise endurance in patients with chronic hypercapnic 
      respiratory failure.
PG  - 459-67
AB  - BACKGROUND/PURPOSE: This study was designed to investigate the effects of 6 
      months of nocturnal nasal positive pressure ventilation (NNPPV) on respiratory 
      muscle function and exercise capacity in patients with chronic respiratory 
      failure. METHODS: A prospective, randomized, controlled design was used. 
      Twenty-nine patients with chronic respiratory failure were enrolled and allocated 
      to either the NNPPV (n = 14) or control group (n = 15). Patients in the NNPPV 
      group received bi-level positive pressure ventilation via nasal mask for 6 
      consecutive months. Arterial blood gas, respiratory muscle assessment and 
      6-minute walk test (6MWT) were performed before and after the 6-month NNPPV 
      intervention. Respiratory muscle function was assessed using the variables of 
      maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and 
      maximum voluntary ventilation (MVV). RESULTS: Subjects in the NNPPV group showed 
      a significant improvement in blood gas exchange and increased 6-minute walk 
      distance (6MWD) compared to baseline and the control group. The 6MWD was 
      significantly increased from 257.1 +/- 114.1 to 345.2 +/- 109.9 m (34.3%) in the 
      NNPPV group. NNPPV also significantly improved MVV and Pimax relative to 
      baseline. MVV was significantly increased from 19.2 +/- 6.5 to 22.3 +/- 7.1 L/min 
      (16.1%) in the NNPPV group (p < 0.05). Furthermore, there was a significant 
      correlation between the magnitude of MVV improvement and 6MWD change. CONCLUSION: 
      The 6-month NNPPV treatment significantly decreased the partial pressure of 
      carbon dioxide and improved daytime respiratory muscle function, thus 
      contributing to exercise-capacity increase in patients with chronic respiratory 
      failure.
FAU - Chiang, Ling-Ling
AU  - Chiang LL
AD  - School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan.
FAU - Yu, Chih-Teng
AU  - Yu CT
FAU - Liu, Chien-Ying
AU  - Liu CY
FAU - Lo, Yu-Lun
AU  - Lo YL
FAU - Kuo, Han-Pin
AU  - Kuo HP
FAU - Lin, Horng-Chyuan
AU  - Lin HC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - *Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Hypercapnia/*therapy
MH  - Male
MH  - Middle Aged
MH  - Physical Endurance
MH  - *Positive-Pressure Respiration
MH  - Prospective Studies
MH  - Pulmonary Gas Exchange
MH  - Respiratory Insufficiency/*therapy
MH  - *Respiratory Muscles
EDAT- 2006/06/28 09:00
MHDA- 2006/08/03 09:00
CRDT- 2006/06/28 09:00
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2006/08/03 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
AID - S0929-6646(09)60185-6 [pii]
AID - 10.1016/S0929-6646(09)60185-6 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2006 Jun;105(6):459-67. doi: 10.1016/S0929-6646(09)60185-6.