PMID- 1680115
OWN - NLM
STAT- MEDLINE
DCOM- 19911024
LR  - 20240324
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 82
IP  - 8
DP  - 1991 Aug
TI  - Allele loss on chromosome 11 in a pituitary tumor from a patient with multiple 
      endocrine neoplasia type 1.
PG  - 886-9
AB  - We have examined the allele loss of chromosome 11 in a pituitary tumor from a 
      patient with familial multiple endocrine neoplasia type 1 (MEN 1). The extensive 
      loss of chromosome 11, including loci of D11S149, HRAS1 and F2, was detected by 
      the loss of heterozygosity. All of the lost alleles of these loci were 
      transmitted from the unaffected father and not from an affected mother. This is 
      the first evidence of allele loss of chromosome 11 in a pituitary tumor of MEN 1 
      and supports the idea that similar allelic deletion of MEN1 locus on chromosome 
      11 is the common genetic basis for tumorigenesis in the pituitary, endocrine 
      pancreas, and parathyroid gland in MEN 1.
FAU - Yoshimoto, K
AU  - Yoshimoto K
AD  - Otsuka Department of Clinical and Molecular Nutrition, University of Tokushima.
FAU - Iwahana, H
AU  - Iwahana H
FAU - Kubo, K
AU  - Kubo K
FAU - Saito, S
AU  - Saito S
FAU - Itakura, M
AU  - Itakura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Base Sequence
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Pituitary Neoplasms/*genetics
PMC - PMC5918587
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
PMCR- 1991/08/01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
PHST- 1991/08/01 00:00 [pmc-release]
AID - CAE886 [pii]
AID - 10.1111/j.1349-7006.1991.tb01916.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1991 Aug;82(8):886-9. doi: 10.1111/j.1349-7006.1991.tb01916.x.