PMID- 16802000
OWN - NLM
STAT- MEDLINE
DCOM- 20060810
LR  - 20190608
IS  - 0828-282X (Print)
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 22
IP  - 8
DP  - 2006 Jun
TI  - Coronary artery disease progression is associated with C-reactive protein and 
      conventional risk factors but not soluble CD40 ligand.
PG  - 691-6
AB  - BACKGROUND: Coronary artery disease (CAD) is a major cause of death worldwide. 
      Epidemiological studies have documented conventional risk factors; however, no 
      studies to date have addressed the roles of soluble CD40 ligand (sCD40L) and 
      monocyte chemoattractant protein-1 (MCP-1), and there have been few reports on 
      other novel risk factors in CAD progression. The aim of the present study was to 
      explore the roles of novel and conventional risk factors in CAD progression. 
      METHODS: Patients with stable angina pectoris who underwent repeat coronary 
      angiograms and had serum samples at the time of their first catheterization 
      between March 1999 and January 2004 were enrolled. Those who had progression of 
      coronary atherosclerosis were classified into the progression group (n = 66). 
      Those who did not have CAD progression were classified into the nonprogression 
      group (n = 124). RESULTS: There were more cases of diabetes mellitus (36% versus 
      20%; P = 0.024) and more men (92% versus 81%; P = 0.040) in the CAD progression 
      group than in the nonprogression group, respectively. The progression group also 
      had poorer lipid profiles than the nonprogression group, including higher total 
      cholesterol (188+/-42 mg/dL versus 173+/-39 mg/dL, respectively; P = 0.014) and 
      low density lipoprotein cholesterol (122+/-38 mg/dL versus 112+/-36 mg/dL, 
      respectively; P = 0.025). In terms of inflammatory markers, progression patients 
      had higher baseline high-sensitivity C-reactive protein (hs-CRP) concentrations 
      (P = 0.018), which was also related to the subsequent angiographic severity score 
      changes; however, sCD40L (6182+/-4352 pg/mL versus 6244+/-4602 pg/mL; P = 0.961), 
      MCP-1 (427+/-540 pg/mL versus 341+/-128 pg/mL; P = 0.580) and adhesion molecules 
      concentrations were indifferent between the progression group and the 
      nonprogression group, respectively. Using a multivariate logistical regression 
      model, the ORs for predicting progression were 2.19 for diabetes mellitus, 2.04 
      for hypercholesterolemia and 1.52 for hs-CRP (P < 0.05). CONCLUSION: In the 
      present study, only conventional risk factors, and particularly hs-CRP, were 
      markers for predicting CAD progression. Novel risk factors, such as 
      concentrations of sCD40L, MCP-1 and adhesion molecules, did not play significant 
      roles.
FAU - Liang, Kae-Woei
AU  - Liang KW
AD  - Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Sheu, Wayne Huey-Herng
AU  - Sheu WH
FAU - Lee, Wen-Lieng
AU  - Lee WL
FAU - Liu, Tsun-Jui
AU  - Liu TJ
FAU - Ting, Chih-Tai
AU  - Ting CT
FAU - Chen, Ying-Tsung
AU  - Chen YT
FAU - Lee, Wen-Jane
AU  - Lee WJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Biomarkers)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
EIN - Can J Cardiol. 2007 Oct;23(12):1001
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - CD40 Ligand/*blood
MH  - Cardiac Catheterization
MH  - Coronary Angiography
MH  - Coronary Disease/*blood/diagnosis/epidemiology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC2560562
EDAT- 2006/06/28 09:00
MHDA- 2006/08/11 09:00
PMCR- 2007/06/01
CRDT- 2006/06/28 09:00
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2006/08/11 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
PHST- 2007/06/01 00:00 [pmc-release]
AID - S0828-282X(06)70938-2 [pii]
AID - cjc220691 [pii]
AID - 10.1016/s0828-282x(06)70938-2 [doi]
PST - ppublish
SO  - Can J Cardiol. 2006 Jun;22(8):691-6. doi: 10.1016/s0828-282x(06)70938-2.