PMID- 16802112
OWN - NLM
STAT- MEDLINE
DCOM- 20061215
LR  - 20131121
IS  - 1389-5729 (Print)
IS  - 1389-5729 (Linking)
VI  - 7
IP  - 2
DP  - 2006 Apr
TI  - Chronic treatment with physiological doses of estradiol affects the GH-IGF-1 axis 
      and fat metabolism in young and middle-aged ovariectomized rats.
PG  - 91-100
AB  - Estrogen deficiency may be partly responsible for the metabolic syndrome and the 
      condition may be reversible with hormone replacement therapy. However, after the 
      heart and estrogen/progestin replacement study and the women's health initiative 
      study the prospect of HRT on CVD has changed dramatically. As the pituitary and 
      the liver are targets for estrogen action we assessed the effect of ovariectomy 
      (OVX) and long-term (3 months) estradiol (E2) treatment by means of 
      subcutaneously (s.c.) implanted silastic capsules on pituitary and liver function 
      in young and middle-aged female rats. Our results demonstrate that triglyceride 
      serum levels increased, whereas insulin-like growth factor-1 (IGF-1), high 
      density lipoprotein cholesterol (HDL), and glucose levels decreased during the 
      transition from young to middle-age. E2 treatment increased dose-independently 
      growth hormone (GH) secretion. IGF-1 levels were increased upon OVX in 
      middle-aged rats and the high dose of E2 decreased IGF-1 concentrations in both 
      age groups. Cholesterol concentrations increased after OVX and were attenuated by 
      E2 administration in middle-aged rats. Both, low density lipoprotein cholesterol 
      (LDL) and HDL levels raised after castration and both parameters decreased in 
      response to E2 in young and middle-aged rats. Glucose serum concentrations 
      decreased after E2 treatment in all animals. Taken together, our results clearly 
      demonstrate that the pituitary and the liver metabolism of middle-aged rats 
      remain susceptible to the influence of OVX and E2 treatment.
FAU - Bottner, M
AU  - Bottner M
AD  - Department of Anatomy, University of Lubeck, D-23538, Lubeck, Germany. 
      boettner@anat.uni-luebeck.de
FAU - Wuttke, W
AU  - Wuttke W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biogerontology
JT  - Biogerontology
JID - 100930043
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 4TI98Z838E (Estradiol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Growth Hormone/*metabolism
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Lipids/*blood
MH  - Liver/drug effects/metabolism
MH  - *Ovariectomy
MH  - Pituitary Gland/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Triglycerides/blood
EDAT- 2006/06/28 09:00
MHDA- 2006/12/16 09:00
CRDT- 2006/06/28 09:00
PHST- 2005/08/22 00:00 [received]
PHST- 2005/12/15 00:00 [accepted]
PHST- 2006/06/28 09:00 [pubmed]
PHST- 2006/12/16 09:00 [medline]
PHST- 2006/06/28 09:00 [entrez]
AID - 10.1007/s10522-006-6496-9 [doi]
PST - ppublish
SO  - Biogerontology. 2006 Apr;7(2):91-100. doi: 10.1007/s10522-006-6496-9.