PMID- 16803516
OWN - NLM
STAT- MEDLINE
DCOM- 20070227
LR  - 20181030
IS  - 1048-891X (Print)
IS  - 1048-891X (Linking)
VI  - 16
IP  - 3
DP  - 2006 May-Jun
TI  - Association between HLA-DQB1 and cervical dysplasia in Vietnamese women.
PG  - 1269-77
AB  - Host genetic background seems to play a key role in cervical carcinogenesis as 
      only a small subset of women infected with high-risk human papillomaviruses 
      (HPVs) develop cervical cancer. The rate of cervical cancer in Vietnamese women 
      is notably high. To explore the association of human leukocyte antigen (HLA)-DQB1 
      alleles, HPV infection, and cervical dysplasia in this population, cervical 
      smears were obtained from 101 women attending the obstetrics and gynecology 
      clinic of Da Nang General Hospital in Vietnam. Besides the Papanicolaou test, HPV 
      and HLA-DQB1 genotyping were performed using cervical smear DNA. Additionally, a 
      subset of 30 blood samples was used as the gold standard for HLA genotyping. 
      HLA-DQB1 alleles showed no association with HPV infection status. However, a 
      positive association with cervical dysplasia was found for HLA-DQB1*0302 (P= 
      0.0229, relative risk (RR) = 4.737) and HLA-DQB1*0601 (P= 0.0370, RR = 4.038), 
      whereas HLA-DQB1*0301 (P= 0.0152, RR = 0.221) was found negatively associated. 
      The low diversity of HLA-DQB1 alleles, wide spectrum of HPV genotypes, and high 
      prevalence of HPV 16 and HPV 18 observed in the study population suggest a 
      permissive/susceptible genetic background that deserves further research. Total 
      concordance of HLA-DQB1 genotyping results between blood and cervical cells 
      confirms the potential value of cervical smears as an effective tool for the 
      development of cervical cancer biomarkers.
FAU - Lema, C
AU  - Lema C
AD  - Life Sciences & Health Group, Houston Advanced Research Center, 4800 Research 
      Forest Drive, The Woodlands, TX 77381, USA.
FAU - Fuessel-Haws, A L
AU  - Fuessel-Haws AL
FAU - Lewis, L R
AU  - Lewis LR
FAU - Rady, P L
AU  - Rady PL
FAU - Lee, P
AU  - Lee P
FAU - Turbat-Herrera, E A
AU  - Turbat-Herrera EA
FAU - He, Q
AU  - He Q
FAU - Nguyen, L T
AU  - Nguyen LT
FAU - Tyring, S K
AU  - Tyring SK
FAU - Dao, D D
AU  - Dao DD
LA  - eng
GR  - 1R03 CA 030730-01/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
RN  - 0 (DNA, Viral)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cervix Uteri/cytology/pathology
MH  - DNA/blood/isolation & purification
MH  - DNA, Viral/isolation & purification
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Middle Aged
MH  - Papanicolaou Test
MH  - Papillomaviridae/genetics/isolation & purification
MH  - Papillomavirus Infections/*genetics
MH  - Uterine Cervical Dysplasia/epidemiology/*genetics
MH  - Vaginal Smears
MH  - Vietnam/epidemiology
EDAT- 2006/06/29 09:00
MHDA- 2007/02/28 09:00
CRDT- 2006/06/29 09:00
PHST- 2006/06/29 09:00 [pubmed]
PHST- 2007/02/28 09:00 [medline]
PHST- 2006/06/29 09:00 [entrez]
AID - IJG459 [pii]
AID - 10.1111/j.1525-1438.2006.00459.x [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2006 May-Jun;16(3):1269-77. doi: 
      10.1111/j.1525-1438.2006.00459.x.