PMID- 16803822
OWN - NLM
STAT- MEDLINE
DCOM- 20061016
LR  - 20221207
IS  - 0002-8177 (Print)
IS  - 0002-8177 (Linking)
VI  - 137
IP  - 7
DP  - 2006 Jul
TI  - The use of adult stem cells in rebuilding the human face.
PG  - 961-72
AB  - BACKGROUND: Stem cells have been isolated from a variety of embryonic and 
      postnatal (adult) tissues, including bone marrow. Bone marrow stromal cells 
      (BMSCs), which are non-blood-forming cells in marrow, contain a subset of 
      skeletal stem cells (SSCs) that are able to regenerate all types of skeletal 
      tissue: bone, cartilage, blood-supportive stromal cells and marrow fat cells. 
      METHODS: Bone marrow suspensions are placed into culture for analysis of their 
      biological character and for expansion of their number. The resulting populations 
      of cells are used in a variety of assays to establish the existence of an adult 
      SSC, and the ability of BMSC populations to regenerate hard tissues in the 
      craniofacial region, in conjunction with appropriate scaffolds. RESULTS: 
      Single-cell analysis established the existence of a true adult SSC in bone 
      marrow. Populations of ex vivo expanded BMSCs (a subset of which are SSCs) are 
      able to regenerate a bone/marrow organ. In conjunction with appropriate 
      scaffolds, these cells can be used to regenerate bone in a variety of 
      applications. CONCLUSIONS: BMSCs have the potential to re-create tissues of the 
      craniofacial region to restore normal structure and function in reconstructing 
      the hard tissues of a face. Ex vivo expanded BMSCs with scaffolds have been used 
      in a limited number of patients to date, but likely will be used more extensively 
      in the near future.
FAU - Robey, Pamela Gehron
AU  - Robey PG
AD  - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and 
      Craniofacial Research, National Institutes of Health, Department of Health and 
      Human Services, Bethesda, MD 20892, USA. probey@dir.nidcr.nih.gov
FAU - Bianco, Paolo
AU  - Bianco P
LA  - eng
GR  - GGP04263/TI_/Telethon/Italy
GR  - ImNIH/Intramural NIH HHS/United States
GR  - 1 Z01 DE000649/DE/NIDCR NIH HHS/United States
GR  - 1 Z01 DE000380/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Adult
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - Bone Regeneration
MH  - Bone Transplantation/*methods
MH  - Cell Culture Techniques
MH  - Colony-Forming Units Assay
MH  - Facial Bones/physiology/*surgery
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Multipotent Stem Cells/cytology
MH  - Plastic Surgery Procedures/*methods
MH  - Regenerative Medicine
MH  - Stromal Cells/cytology/transplantation
MH  - Tissue Engineering/*methods
RF  - 59
EDAT- 2006/06/29 09:00
MHDA- 2006/10/17 09:00
CRDT- 2006/06/29 09:00
PHST- 2006/06/29 09:00 [pubmed]
PHST- 2006/10/17 09:00 [medline]
PHST- 2006/06/29 09:00 [entrez]
AID - S0002-8177(14)64922-9 [pii]
AID - 10.14219/jada.archive.2006.0317 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2006 Jul;137(7):961-72. doi: 10.14219/jada.archive.2006.0317.