PMID- 16804198
OWN - NLM
STAT- MEDLINE
DCOM- 20060803
LR  - 20190513
IS  - 1084-2020 (Print)
IS  - 1084-2020 (Linking)
VI  - 47
IP  - 3
DP  - 2006
TI  - Feline models of type 2 diabetes mellitus.
PG  - 234-42
AB  - Feline diabetes mellitus (FDM) closely resembles human type 2 diabetes mellitus 
      (T2DM) in many respects including clinical, physiological, and pathological 
      features of the disease. These features include age of onset of FDM in middle 
      age, association with obesity, residual but declining insulin secretion, 
      development of islet amyloid deposits, loss of approximately 50% of beta-cell 
      mass, and development of complications in several organ systems including 
      peripheral polyneuropathy and retinopathy. Many of the pathological aspects of 
      the disease are also experimentally inducible, facilitating study of the 
      pathogenesis of these lesions. Physiological aspects of FDM and obesity are also 
      well studied in the cat and provide an excellent basis for comparative studies of 
      human T2DM. The relatively short generation time of cats along with breed 
      predispositions to development of FDM may allow for more rapid screening and 
      identification of genetic markers for diabetes susceptibility. FDM, in both 
      spontaneous and inducible forms, therefore provides a good animal model of human 
      T2DM and may provide additional insights into the pathogenesis of this important 
      condition.
FAU - Henson, Michael S
AU  - Henson MS
AD  - Veterinary Clinical Sciences Department, College of Veterinary Medicine, 
      University of Minnesota, St. Paul, MN, USA.
FAU - O'Brien, Timothy D
AU  - O'Brien TD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - ILAR J
JT  - ILAR journal
JID - 9516416
SB  - IM
MH  - Animals
MH  - Cat Diseases/genetics/*metabolism/physiopathology
MH  - Cats
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism/physiopathology/*veterinary
MH  - *Disease Models, Animal
MH  - Humans
RF  - 132
EDAT- 2006/06/29 09:00
MHDA- 2006/08/04 09:00
CRDT- 2006/06/29 09:00
PHST- 2006/06/29 09:00 [pubmed]
PHST- 2006/08/04 09:00 [medline]
PHST- 2006/06/29 09:00 [entrez]
AID - 10.1093/ilar.47.3.234 [doi]
PST - ppublish
SO  - ILAR J. 2006;47(3):234-42. doi: 10.1093/ilar.47.3.234.