PMID- 16804312
OWN - NLM
STAT- MEDLINE
DCOM- 20060913
LR  - 20061130
IS  - 0014-312X (Print)
IS  - 0014-312X (Linking)
VI  - 38
IP  - 3
DP  - 2006
TI  - Effects of unfractionated heparin and low-molecular-weight heparin on colonic 
      anastomoses in the presence of experimental peritonitis.
PG  - 353-7
AB  - BACKGROUND: We aimed at investigating the effects of unfractionated heparin (UFH) 
      and low-molecular-weight heparin (LMWH) on the healing process of colonic 
      anastomoses in the presence of peritonitis which is known to adversely affect the 
      healing process. STUDY DESIGN: Three groups of Wistar albino rats (n = 15 in each 
      group) with experimental fecal peritonitis were studied. A 1-cm colonic segment 
      was resected, and an end-to-end anastomosis was performed. The control group 
      (group 1) was given no treatment; group 2 animals received 50 IU/kg s.c. UFH 
      twice a day, and group 3 rats received LMWH at a dose of 1.5 mg/kg daily for 7 
      days postoperatively. Relaparotomy was done on day 7 in the surviving rats. The 
      rats were sacrificed by resection of the colonic segment. The anastomosis 
      bursting pressures were measured and the tissue samples from anastomosis lines 
      were histopathologically examined. RESULTS: The bursting pressures were 
      significantly higher in UFH and LMWH groups as compared with the controls (p = 
      0.021 and p < 0.001, respectively), while there was no statistically significant 
      difference between UFH and LMWH groups. Positive bacterial culture results were 
      more common in controls (90%) than in the other two groups (p = 0.029 and p = 
      0.002, respectively). Also the polymorphonuclear leukocyte counts were higher (p 
      = 0.005) and the fibrin formation more common (p = 0.007) in the controls. On the 
      other hand, the number of fibroblasts was higher (p = 0.002) and collagen 
      formation and revascularization more frequent (p = 0.001 and p = 0.001, 
      respectively) in the UFH and LMWH groups. CONCLUSION: UFH and LMWH may have 
      positive effects on the healing process of colonic anastomoses in the presence of 
      peritonitis.
FAU - Gunerhan, Yusuf
AU  - Gunerhan Y
AD  - 2nd Surgical Clinics, Haydarpasa Numune Education and Research Hospital, 
      Istanbul, Turkey. ygunerhan@superonline.com
FAU - Koksal, Neset
AU  - Koksal N
FAU - Gul, Ozden
AU  - Gul O
FAU - Uzun, Mehmet Ali
AU  - Uzun MA
FAU - Gunes, Pembegul
AU  - Gunes P
FAU - Adaleti, Riza
AU  - Adaleti R
LA  - eng
PT  - Journal Article
DEP - 20060628
PL  - Switzerland
TA  - Eur Surg Res
JT  - European surgical research. Europaische chirurgische Forschung. Recherches 
      chirurgicales europeennes
JID - 0174752
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Anastomosis, Surgical
MH  - Animals
MH  - Anticoagulants/*pharmacology
MH  - Collagen/metabolism
MH  - Colon/microbiology/pathology/*surgery
MH  - Feces
MH  - Fibroblasts/metabolism/pathology
MH  - Heparin, Low-Molecular-Weight/*pharmacology
MH  - Male
MH  - Peritonitis/*drug therapy/pathology/physiopathology
MH  - Pressure
MH  - Rats
MH  - Rats, Wistar
MH  - Wound Healing/*drug effects
EDAT- 2006/06/29 09:00
MHDA- 2006/09/14 09:00
CRDT- 2006/06/29 09:00
PHST- 2006/03/03 00:00 [received]
PHST- 2006/05/15 00:00 [accepted]
PHST- 2006/06/29 09:00 [pubmed]
PHST- 2006/09/14 09:00 [medline]
PHST- 2006/06/29 09:00 [entrez]
AID - 94257 [pii]
AID - 10.1159/000094257 [doi]
PST - ppublish
SO  - Eur Surg Res. 2006;38(3):353-7. doi: 10.1159/000094257. Epub 2006 Jun 28.