PMID- 16806451
OWN - NLM
STAT- MEDLINE
DCOM- 20070712
LR  - 20220408
IS  - 0093-691X (Print)
IS  - 0093-691X (Linking)
VI  - 66
IP  - 8
DP  - 2006 Nov
TI  - Reproductive performance of gilts following vaccination and subsequent 
      heterologous challenge with European strains of porcine reproductive and 
      respiratory syndrome virus.
PG  - 1884-93
AB  - The objective of this study was to evaluate the efficacy of two commercially 
      available modified live virus vaccines for preventing the reproductive and early 
      postnatal consequences of infecting (challenging) pregnant gilts with virulent 
      porcine reproductive and respiratory syndrome virus (PRRSV). For this purpose 21 
      crossbred gilts were allocated to one or another of four groups (Groups A-D). 
      Group A comprised four gilts neither vaccinated nor challenged; Group B comprised 
      five gilts that were challenged but not vaccinated; Group C comprised seven gilts 
      that were vaccinated (AmervacPRRS) and challenged; Group D comprised five gilts 
      that were vaccinated (Pyrsvac-183) and challenged. Vaccination was 24 days before 
      conception, and challenge was at 90 days of gestation. Both vaccine viruses and 
      the challenge virus were European strains but differed in part from one another 
      on the basis of their genetic (nucleotide) sequence. After challenge PRRSV was 
      isolated from five (100%), four (57%), and two (40%) of the gilts of Groups B, C 
      and D, respectively. Although vaccination failed to prevent a detectable viremia 
      in all of the gilts of Groups C and D after they were challenged (or congenital 
      infection of some of their pigs), it did provide a statistically significant 
      level of protection in regard to the incidence of congenital infection, 
      reproductive performance, and pig health and viability. Namely, for Groups C and 
      D the numbers of liveborn pigs/litter and healthy pigs/litter throughout the 
      early postnatal period were similar to those of Group A (nonvaccinated and 
      nonchallenged) and far exceeded those of Group B (nonvaccinated and challenged).
FAU - Scortti, Mariela
AU  - Scortti M
AD  - Dpto. de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de 
      Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
FAU - Prieto, Cinta
AU  - Prieto C
FAU - Simarro, Isabel
AU  - Simarro I
FAU - Castro, Jose Maria
AU  - Castro JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060627
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/virology
MH  - Antibodies, Viral/blood
MH  - Base Sequence
MH  - Birth Weight
MH  - Female
MH  - Fetus/virology
MH  - Litter Size
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/transmission
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/isolation & 
      purification/pathogenicity
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/prevention & control/*veterinary
MH  - Pregnancy Outcome/veterinary
MH  - Random Allocation
MH  - *Reproduction
MH  - Swine
MH  - Vaccination/*veterinary
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/immunology
MH  - Viremia/veterinary
EDAT- 2006/06/30 09:00
MHDA- 2007/07/13 09:00
CRDT- 2006/06/30 09:00
PHST- 2006/02/09 00:00 [received]
PHST- 2006/04/19 00:00 [revised]
PHST- 2006/04/25 00:00 [accepted]
PHST- 2006/06/30 09:00 [pubmed]
PHST- 2007/07/13 09:00 [medline]
PHST- 2006/06/30 09:00 [entrez]
AID - S0093-691X(06)00290-1 [pii]
AID - 10.1016/j.theriogenology.2006.04.043 [doi]
PST - ppublish
SO  - Theriogenology. 2006 Nov;66(8):1884-93. doi: 
      10.1016/j.theriogenology.2006.04.043. Epub 2006 Jun 27.