PMID- 16807646
OWN - NLM
STAT- MEDLINE
DCOM- 20061030
LR  - 20131121
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 96
IP  - 1
DP  - 2006 Jul
TI  - Antiphospholipid antibodies and hyperhomocysteinaemia in patients with vascular 
      occlusive disease.
PG  - 19-23
AB  - Hyperhomocysteinemia (HHcy), lupus anticoagulant (LA) and anticardiolipin 
      antibodies (ACA) are independent risk factors for thrombosis. Even though risks 
      are cumulative, the clinical impact of the association is unknown. Preliminary 
      data suggested that HHcy might be associated with transient LA and ACA, 
      disappearing after lowering HHcy. We prospectively evaluated the association of 
      HHcy and LA/ACA, the effect of lowering HHcy with folic acid in LA behavior, and 
      the correlation of the initial dRVVT with LA behavior after folic acid in 210 
      patients with thrombosis and adverse pregnancy outcomes. Prevalence of HHcy among 
      patients with LA/ACA was 40%. Thirty-one patients exhibited only HHcy (15%; Group 
      1), 106 (50%; Group 2) had only LA/ACA, while 73 (35%; Group 3) had both. After 
      therapy, 63% and 64% of LA/ACA remained positive in Group 3 and 2, respectively. 
      We observed a trend towards a more positive dRVVT in persistent LA after lowering 
      HHcy. No differences in clinical presentation or in outcomes after two years of 
      followup were observed among the groups. Even though the association of HHcy and 
      LA/ACA is common in patients with thrombosis, it might have no prognostic 
      implications if Hcy levels are lowered. Currently, no laboratory findings 
      correlate with LA behavior, which is independent of homocysteine levels and 
      vitamin treatment.
FAU - Casais, Patricia
AU  - Casais P
AD  - Departamento de Hemostasia y Trombosis, Instituto de Investigaciones 
      Hematologicas 'Mariano R. Castex', Academia Nacional de Medicina de Buenos Aires, 
      Buenos Aires, Argentina. casais@hematologia.anm.edu.ar
FAU - Meschengieser, Susana S
AU  - Meschengieser SS
FAU - Gennari, Laura C
AU  - Gennari LC
FAU - Alberto, Maria F
AU  - Alberto MF
FAU - Sanchez-Luceros, Analia
AU  - Sanchez-Luceros A
FAU - Blanco, Alicia N
AU  - Blanco AN
FAU - Lazzari, Maria A
AU  - Lazzari MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antiphospholipid/*blood
MH  - Arterial Occlusive Diseases/blood/epidemiology/etiology
MH  - Female
MH  - Folic Acid/pharmacology
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Thrombosis/*blood/*epidemiology/etiology
EDAT- 2006/06/30 09:00
MHDA- 2006/10/31 09:00
CRDT- 2006/06/30 09:00
PHST- 2006/06/30 09:00 [pubmed]
PHST- 2006/10/31 09:00 [medline]
PHST- 2006/06/30 09:00 [entrez]
AID - 06070019 [pii]
AID - 10.1160/TH05-11-0737 [doi]
PST - ppublish
SO  - Thromb Haemost. 2006 Jul;96(1):19-23. doi: 10.1160/TH05-11-0737.