PMID- 16808315
OWN - NLM
STAT- MEDLINE
DCOM- 20060816
LR  - 20170306
VI  - 114
IP  - 2
DP  - 2005 Aug
TI  - [Transient hyponatremia the first symptome of multiple endocrine neoplasia type 1 
      (MEN 1)--case report].
PG  - 768-72
AB  - Transient character of laboratory abnormalities is usually explained as a false 
      result of estimation. Spontaneous disappearance of laboratory abnormalities could 
      be recognized as non-important and contradicting serious disease. Presented case 
      of multiple endocrine neoplasia type 1 (MEN 1) denies these assumptions. 
      Sixty-nine-years old woma was admitted to the internal department because of 
      weakness, fever, dehydration and hypotension--symptom accompanying an upper 
      respiratory infection. Moderate hyponatremia (122.6 mmol/l) was found in a 
      routine laborator examination. All clinical symptoms as well as hyponatremia 
      disappeared during hospitalization. Transient hyponatremi was not ignored. 
      Further laboratory and hormonal investigations were performed. Fasting, morning 
      serum cortisol concentration and 24-hours urinary excretion of free 
      corticosterids were decreased and Synacten stimulation test reveale incomplete 
      cortisol stimulation. Pituitary tumour was found in the CT scan. Moreover blood 
      ionized calcium an parathyroid hormone were elevated. These results revealed 
      secondary adrenal insufficiency, non-functioning pituitary tumor and 
      hyperparathyroidism. Removal of pituitary adenoma was done. Asymptomatic 
      hypercalcemia persists. Presented MEN 1 was atypical because: 1. Usually 
      hyperparathyroidism is the first and most frequent symptom while in our patient 
      the first symptom was transient hyponatremia secondary to the pituitary tumor, 2. 
      was diagnosed in the old age while the majority of MEN 1 patients are younger, 3. 
      asymptomatic course of hypercalcemia indicates that in some of elder patients 
      removal of the parathyroid glands might not be necessary.
FAU - Czarkowski, Marek
AU  - Czarkowski M
AD  - Katedra i Klinika Chorob Wewnetrznych i Endokrynologii AM, Warszawie. 
      mczark@amwaw.edu.pl
FAU - Dabrowska, Justyna
AU  - Dabrowska J
LA  - pol
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Przejsciowa hiponatremia pierwszym objawem zespolu mnogiej gruczolakowatosci typu 
      1 (MEN 1)--przypadek kliniczny.
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged
MH  - Calcium/blood
MH  - Central Nervous System Cysts/complications/*diagnosis/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypercalcemia/blood/diagnosis/etiology
MH  - Hyperparathyroidism/blood/diagnosis/etiology
MH  - Hyponatremia/*blood/*etiology/therapy
MH  - Multiple Endocrine Neoplasia Type 1/blood/complications/*diagnosis
MH  - Parathyroid Neoplasms/blood/complications/*diagnosis
MH  - Pituitary Neoplasms/blood/complications/*diagnosis/surgery
EDAT- 2006/07/01 09:00
MHDA- 2006/08/17 09:00
CRDT- 2006/07/01 09:00
PHST- 2006/07/01 09:00 [pubmed]
PHST- 2006/08/17 09:00 [medline]
PHST- 2006/07/01 09:00 [entrez]
PST - ppublish
SO  - Pol Arch Med Wewn. 2005 Aug;114(2):768-72.