PMID- 16809140
OWN - NLM
STAT- MEDLINE
DCOM- 20060818
LR  - 20131121
IS  - 1556-3650 (Print)
IS  - 1556-3650 (Linking)
VI  - 44
IP  - 4
DP  - 2006
TI  - Ceftazidime overdose-related nonconvulsive status epilepticus after 
      intraperitoneal instillation.
PG  - 383-6
AB  - We report a case of ceftazidime-related nonconvulsive status epilepticus (NCSE) 
      in a 70-year-old female patient with continuous ambulatory peritoneal dialysis 
      (CAPD)-related peritonitis. She was given ceftazidime intravenously which was 
      then changed to intraperitoneal installation after clinical improvement. She 
      received 11 g of ceftazidime via intraperitoneal installation for two days after 
      being discharged from the hospital. Her consciousness was altered with mutism, 
      asterisxis, and horizontal nystagmus. Her EEG showed continuous generalized three 
      spikes-and-wave per second that were abolished after intravenous diazepam. 
      Ceftazidime-related NCSE was suggested and ceftazidime therapy was stopped. 
      Hemodialysis was done while phenytoin was also given to control the convulsions. 
      Her consciousness improved after hemodialysis. Serum ceftazidime measured before 
      and after hemodialysis on the second and third day were 105.2/39.4, 36.2/5.2 
      microg/mL (normal peak level 55 microg/mL), respectively. Repeated evaluation on 
      day 6 showed normal EEG without epileptiform activity. She was later discharged 
      with full recovery.
FAU - Vannaprasaht, Suda
AU  - Vannaprasaht S
AD  - Department of Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen 
      University, Khon Kaen, Thailand. sudvan@kku.ac.th
FAU - Tawalee, Arporn
AU  - Tawalee A
FAU - Mayurasakorn, Nutdhakarn
AU  - Mayurasakorn N
FAU - Yodwut, Chattanong
AU  - Yodwut C
FAU - Bansong, Ratiporn
AU  - Bansong R
FAU - Reungjui, Sirirat
AU  - Reungjui S
FAU - Tiamkao, Somsak
AU  - Tiamkao S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Toxicol (Phila)
JT  - Clinical toxicology (Philadelphia, Pa.)
JID - 101241654
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anticonvulsants)
RN  - 6158TKW0C5 (Phenytoin)
RN  - 9M416Z9QNR (Ceftazidime)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage/blood/*poisoning
MH  - Anticonvulsants/therapeutic use
MH  - Ceftazidime/administration & dosage/blood/*poisoning
MH  - Drug Overdose
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Injections, Intraperitoneal
MH  - Phenytoin/therapeutic use
MH  - Renal Dialysis
MH  - Status Epilepticus/*chemically induced/drug therapy/therapy
EDAT- 2006/07/01 09:00
MHDA- 2006/08/19 09:00
CRDT- 2006/07/01 09:00
PHST- 2006/07/01 09:00 [pubmed]
PHST- 2006/08/19 09:00 [medline]
PHST- 2006/07/01 09:00 [entrez]
AID - N70V17758GP2760K [pii]
AID - 10.1080/15563650600671753 [doi]
PST - ppublish
SO  - Clin Toxicol (Phila). 2006;44(4):383-6. doi: 10.1080/15563650600671753.