PMID- 16809782
OWN - NLM
STAT- MEDLINE
DCOM- 20060811
LR  - 20181113
IS  - 0270-7306 (Print)
IS  - 1098-5549 (Electronic)
IS  - 0270-7306 (Linking)
VI  - 26
IP  - 14
DP  - 2006 Jul
TI  - Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated 
      NF-kappaB activation.
PG  - 5497-508
AB  - CARMA1 is a central regulator of NF-kappaB activation in lymphocytes. CARMA1 and 
      Bcl10 functionally interact and control NF-kappaB signaling downstream of the 
      T-cell receptor (TCR). Computational analysis of expression neighborhoods of 
      CARMA1-Bcl10MALT 1 for enrichment in kinases identified calmodulin-dependent 
      protein kinase II (CaMKII) as an important component of this pathway. Here we 
      report that Ca(2+)/CaMKII is redistributed to the immune synapse following T-cell 
      activation and that CaMKII is critical for NF-kappaB activation induced by TCR 
      stimulation. Furthermore, CaMKII enhances CARMA1-induced NF-kappaB activation. 
      Moreover, we have shown that CaMKII phosphorylates CARMA1 on Ser109 and that the 
      phosphorylation facilitates the interaction between CARMA1 and Bcl10. These 
      results provide a novel function for CaMKII in TCR signaling and CARMA1-induced 
      NF-kappaB activation.
FAU - Ishiguro, Kazuhiro
AU  - Ishiguro K
AD  - Center for Computational and Integrative Biology, Massachusetts General Hospital, 
      Boston, MA 02114, USA.
FAU - Green, Todd
AU  - Green T
FAU - Rapley, Joseph
AU  - Rapley J
FAU - Wachtel, Heather
AU  - Wachtel H
FAU - Giallourakis, Cosmas
AU  - Giallourakis C
FAU - Landry, Aimee
AU  - Landry A
FAU - Cao, Zhifang
AU  - Cao Z
FAU - Lu, Naifang
AU  - Lu N
FAU - Takafumi, Ando
AU  - Takafumi A
FAU - Goto, Hidemi
AU  - Goto H
FAU - Daly, Mark J
AU  - Daly MJ
FAU - Xavier, Ramnik J
AU  - Xavier RJ
LA  - eng
GR  - P30 DK040561/DK/NIDDK NIH HHS/United States
GR  - P30 DK040561-11/DK/NIDDK NIH HHS/United States
GR  - P30 DK043351/DK/NIDDK NIH HHS/United States
GR  - DK43351/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (B-Cell CLL-Lymphoma 10 Protein)
RN  - 0 (BCL10 protein, human)
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
RN  - EC 4.6.1.2 (CARD11 protein, human)
RN  - EC 4.6.1.2 (Guanylate Cyclase)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/metabolism
MH  - Amino Acid Sequence
MH  - Apoptosis Regulatory Proteins/genetics/*metabolism
MH  - B-Cell CLL-Lymphoma 10 Protein
MH  - CARD Signaling Adaptor Proteins
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/genetics/*metabolism
MH  - Caspases/genetics/metabolism
MH  - Cell Line
MH  - Guanylate Cyclase/genetics/*metabolism
MH  - Humans
MH  - Jurkat Cells
MH  - Lymphocyte Activation
MH  - Molecular Sequence Data
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Mutagenesis, Site-Directed
MH  - NF-kappa B/genetics/*metabolism
MH  - Neoplasm Proteins/genetics/metabolism
MH  - Phosphorylation
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - Recombinant Proteins/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - T-Lymphocytes/immunology/metabolism
MH  - Tumor Necrosis Factor-alpha/pharmacology
PMC - PMC1592706
EDAT- 2006/07/01 09:00
MHDA- 2006/08/12 09:00
PMCR- 2006/11/01
CRDT- 2006/07/01 09:00
PHST- 2006/07/01 09:00 [pubmed]
PHST- 2006/08/12 09:00 [medline]
PHST- 2006/07/01 09:00 [entrez]
PHST- 2006/11/01 00:00 [pmc-release]
AID - 26/14/5497 [pii]
AID - 2469-05 [pii]
AID - 10.1128/MCB.02469-05 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2006 Jul;26(14):5497-508. doi: 10.1128/MCB.02469-05.