PMID- 1681470
OWN - NLM
STAT- MEDLINE
DCOM- 19911121
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 41
IP  - 10
DP  - 1991 Oct
TI  - Immunocytochemical analysis of the cellular infiltrate in brain lesions in 
      subacute sclerosing panencephalitis.
PG  - 1639-42
AB  - We studied lymphocyte subsets and major histocompatibility complex (MHC) class II 
      antigens in frozen brain tissues from three patients with subacute sclerosing 
      panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs 
      consisted predominantly of T cells and MHC class II-positive cells. In the 
      parenchymal lesions, there were frequent B and CD4+ cells. MHC class II-positive 
      cells were also diffusely distributed throughout the parenchyma. There were more 
      CD4+ than CD8+ cells both in the parenchyma and in the perivascular cuffs. These 
      findings suggest an overrepresentation of CD4+ cells in SSPE lesions and that 
      CD4+ cells may be involved in the pathogenesis of SSPE.
FAU - Nagano, I
AU  - Nagano I
AD  - Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
FAU - Nakamura, S
AU  - Nakamura S
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Kogure, K
AU  - Kogure K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Antigens, CD)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Antigens, CD
MH  - Brain/*immunology/pathology
MH  - CD4-Positive T-Lymphocytes
MH  - Child, Preschool
MH  - Female
MH  - Histocompatibility Antigens Class II/*chemistry
MH  - Humans
MH  - Immunohistochemistry
MH  - Killer Cells, Natural
MH  - Male
MH  - Subacute Sclerosing Panencephalitis/*immunology/pathology
MH  - *T-Lymphocytes
MH  - T-Lymphocytes, Regulatory
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1212/wnl.41.10.1639 [doi]
PST - ppublish
SO  - Neurology. 1991 Oct;41(10):1639-42. doi: 10.1212/wnl.41.10.1639.