PMID- 16814802
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20061115
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 135
IP  - 1
DP  - 2006 Jul
TI  - The intradermal Leishmanin reaction induces antigen-specific maturation of canine 
      dendritic cells with up-regulation of MHCII synthesis and expression.
PG  - 17-24
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that reside in 
      many tissues, including the skin. This study showed that intradermal injection of 
      leishmanin in Leishmania infantum-infected dogs induced the "up-regulation" of 
      surface MHCII expression, associated with progressive ultrastrucutural changes 
      characteristic of DC maturation, including the formation of multilaminar MHC 
      class II-containing compartments and arrays of tubulo-vesicular structures. These 
      changes were not observed in control dogs from L. infantum non-endemic areas. The 
      results indicated that canine DCs were effector cells in delayed-type 
      hypersensitivity, that the leishmanin reaction was specific for a cell-mediated 
      reaction to L. infantum in infected dogs, and that canine DCs possessed 
      ultrastructural organelles reminiscent of those in activated human DCs.
FAU - Sacchi, L
AU  - Sacchi L
AD  - Department of Animal Biology, University of Pavia, Italy.
FAU - Calvi, L E
AU  - Calvi LE
FAU - Kramer, L H
AU  - Kramer LH
FAU - Ferroglio, E
AU  - Ferroglio E
FAU - Grandi, G
AU  - Grandi G
FAU - Clementi, E
AU  - Clementi E
FAU - Corona, S
AU  - Corona S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20060630
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Antigens)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (leishmanin)
SB  - IM
MH  - Animals
MH  - Antigens/immunology/*metabolism
MH  - Antigens, Protozoan/*immunology
MH  - Dendritic Cells/cytology/*immunology/*metabolism/parasitology/ultrastructure
MH  - Dogs
MH  - Histocompatibility Antigens Class II/biosynthesis/*physiology/ultrastructure
MH  - Leishmania infantum/immunology
MH  - Up-Regulation
EDAT- 2006/07/04 09:00
MHDA- 2006/10/27 09:00
CRDT- 2006/07/04 09:00
PHST- 2005/08/10 00:00 [received]
PHST- 2006/02/21 00:00 [accepted]
PHST- 2006/07/04 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2006/07/04 09:00 [entrez]
AID - S0021-9975(06)00015-6 [pii]
AID - 10.1016/j.jcpa.2006.02.009 [doi]
PST - ppublish
SO  - J Comp Pathol. 2006 Jul;135(1):17-24. doi: 10.1016/j.jcpa.2006.02.009. Epub 2006 
      Jun 30.