PMID- 16814860
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20190816
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 31
IP  - 4
DP  - 2007 Apr
TI  - Temporary blast reduction after immunoglobulin administration for congenital 
      cytomegalovirus infection masking infant leukemia with cryptic MLL rearrangement.
PG  - 553-7
AB  - Differentiation between reactive bone marrow suppression due to viral infection 
      and early stages of leukemia can be difficult particularly in young infants. We 
      report on a 2-month-old girl presenting with pancytopenia and positive markers 
      for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of 
      coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed 
      by the transient regeneration of normal hematopoiesis and reduction of abnormal 
      blastoid cells in the bone marrow following immunoglobulin administration. 
      Molecular diagnosis could only be established using interphase fluorescence in 
      situ hybridization (FISH) analysis which may be considered as a valuable 
      additional diagnostic tool in similar cases.
FAU - Metzler, Markus
AU  - Metzler M
AD  - Department of Pediatrics, University of Erlangen-Nuremberg, Erlangen, Germany. 
      markusmetzler@email.de
FAU - Bruch, Jochen
AU  - Bruch J
FAU - Stachel, Daniel
AU  - Stachel D
FAU - Langer, Thorsten
AU  - Langer T
FAU - Borkhardt, Arndt
AU  - Borkhardt A
FAU - Harbott, Jochen
AU  - Harbott J
FAU - Rascher, Wolfgang
AU  - Rascher W
FAU - Holter, Wolfgang
AU  - Holter W
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060630
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (KMT2A protein, human)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Blast Crisis/*therapy
MH  - Bone Marrow/pathology
MH  - Cytomegalovirus/isolation & purification
MH  - Cytomegalovirus Infections/congenital/*therapy
MH  - Female
MH  - Flow Cytometry
MH  - *Gene Rearrangement
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Immunoglobulins, Intravenous/*administration & dosage
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia, B-Cell/*diagnosis/genetics
MH  - Myeloid-Lymphoid Leukemia Protein/*genetics
MH  - Pancytopenia
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics
EDAT- 2006/07/04 09:00
MHDA- 2007/04/14 09:00
CRDT- 2006/07/04 09:00
PHST- 2006/03/19 00:00 [received]
PHST- 2006/05/15 00:00 [revised]
PHST- 2006/05/19 00:00 [accepted]
PHST- 2006/07/04 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2006/07/04 09:00 [entrez]
AID - S0145-2126(06)00200-1 [pii]
AID - 10.1016/j.leukres.2006.05.020 [doi]
PST - ppublish
SO  - Leuk Res. 2007 Apr;31(4):553-7. doi: 10.1016/j.leukres.2006.05.020. Epub 2006 Jun 
      30.