PMID- 16815745
OWN - NLM
STAT- MEDLINE
DCOM- 20061214
LR  - 20221207
IS  - 1389-9457 (Print)
IS  - 1389-9457 (Linking)
VI  - 7
IP  - 5
DP  - 2006 Aug
TI  - Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients.
PG  - 454-7
AB  - BACKGROUND AND PURPOSE: Investigation of Chinese-Taiwanese patients with 
      excessive sleepiness, but no association with other sleep disorders, and with the 
      presence or absence of cataplexy. PATIENTS AND METHODS: Thirty-five patients, 
      successively referred between 2002 and 2004, underwent polysomnography (PSG), 
      repeat multiple sleep latency test (MSLT), and human leukocyte antigen (HLA) 
      typing. Three patients without cataplexy also had cerebrospinal fluid (CSF) 
      hypocretin measurements. RESULTS: DQB1*0602 was associated with cataplexy in over 
      90% of Chinese-Taiwanese cases. Absence of cataplexy and <2 sleep-onset REM 
      periods (SOREMPs) was seen in only two subjects, but presence of two SOREMPs did 
      not dissociate DQB1*0602 positive and negative or cataplexy positive and negative 
      subjects. As a group, narcoleptics with cataplexy had a higher number of SOREMPs, 
      and the mean sleep latency was much shorter in narcoleptics with cataplexy than 
      in the non-cataplectic patients, independent of the number of SOREMPs. 
      CONCLUSIONS: Chinese-Taiwanese patients with cataplexy present with similar HLA 
      findings as Black and Caucasian patients, but the presence of two or more SOREMPs 
      in Chinese-Taiwanese patients is not a sufficient diagnostic tool to identify 
      narcolepsy. When cataplexy is not present, description of PSG nd HLA findings may 
      be a better approach than using a label with little scientific significance, 
      allowing for better collection of patients' phenotype.
FAU - Huang, Yu-shu
AU  - Huang YS
AD  - Sleep Disorders Clinic, Chang-Gung University Hospital, Taipei, Taiwan, ROC.
FAU - Tafti, Mehdi
AU  - Tafti M
FAU - Guilleminault, Christian
AU  - Guilleminault C
LA  - eng
PT  - Journal Article
DEP - 20060703
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/*genetics
MH  - Biomarkers/blood/cerebrospinal fluid
MH  - Cataplexy/ethnology/physiopathology
MH  - Female
MH  - HLA-DQ Antigens/*blood
MH  - HLA-DQ beta-Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/cerebrospinal fluid
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - Narcolepsy/diagnosis/*ethnology/physiopathology
MH  - Neuropeptides/cerebrospinal fluid
MH  - Orexins
MH  - Phenotype
MH  - Polysomnography
MH  - Sleep, REM
MH  - Taiwan/epidemiology
EDAT- 2006/07/04 09:00
MHDA- 2006/12/15 09:00
CRDT- 2006/07/04 09:00
PHST- 2006/03/24 00:00 [received]
PHST- 2006/05/08 00:00 [revised]
PHST- 2006/05/16 00:00 [accepted]
PHST- 2006/07/04 09:00 [pubmed]
PHST- 2006/12/15 09:00 [medline]
PHST- 2006/07/04 09:00 [entrez]
AID - S1389-9457(06)00166-3 [pii]
AID - 10.1016/j.sleep.2006.05.009 [doi]
PST - ppublish
SO  - Sleep Med. 2006 Aug;7(5):454-7. doi: 10.1016/j.sleep.2006.05.009. Epub 2006 Jul 
      3.